DegronMD

Uniprot ID: O43663

Source protein: Protein regulator of cytokinesis 1

Source gene: PRC1

Class: DEG_APCC_KENBOX_2

Location: 545:549

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9942

ASA_SCORE: 102.58

COIL: 0.5912

CONS_SCORE: 0.4298

DSS_SCORE: 0.5688

HELIX: 0.3782

FCONS_SCORE: 1.0284

RIG_SCORE: 0.7099

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G558C	TCGA-36-2544	OV	TCGA	NKENL	DEG_APCC_KENBOX_2	0.0833
p.G558C	DO27973	OV	ICGC	NKENL	DEG_APCC_KENBOX_2	0.0833
p.G558C	SIDM01111	Ewing's Sarcoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.0833
p.G558C	ACH-000087	Bone Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	0.0833
p.G558C	SK-ES-1	bone	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.0833
p.A544V	TCGA-44-7671	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	0.3056
p.A544V	DO25252	LUAD	ICGC	NKENL	DEG_APCC_KENBOX_2	0.3056
p.G553S	DO230339	COCA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.2222
p.N545D	DO234462	ESAD	ICGC	NKENL	DEG_APCC_KENBOX_2	0.5821
p.N548K	DO228974	LICA	ICGC	NKENL	DEG_APCC_KENBOX_2	0.6918
p.G559W	SIDM00841	Colorectal Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.0556
p.G559W	ACH-000651	Colon/Colorectal Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	0.0556
p.G559W	SW620	large_intestine	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.0556
p.R538C	SIDM00126	Melanoma	GDSC	NKENL	DEG_APCC_KENBOX_2	0.1389
p.R538C	ACH-002147	Skin Cancer	CCLE	NKENL	DEG_APCC_KENBOX_2	0.1389
p.R538C	K2	skin	COSMIC	NKENL	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43663	Protein regulator of cytokinesis 1	DEG_APCC_KENBOX_2	545:549	NKENL	APC,CDC20,FZR1	0.9942	More...
O75113	NEDD4-binding protein 1	DEG_APCC_KENBOX_2	143:147	NKENL	APC,CDC20,FZR1	0.7075	More...
Q6W2J9	BCL-6 corepressor	DEG_APCC_KENBOX_2	888:892	NKENL	APC,CDC20,FZR1	0.9768	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_APCC_KENBOX_2	184:188	NKENL	APC,CDC20,FZR1	0.8788	More...
Q96KR7	Phosphatase and actin regulator 3	DEG_APCC_KENBOX_2	362:366	NKENL	APC,CDC20,FZR1	0.9119	More...
Q9H467	CUE domain-containing protein 2	DEG_APCC_KENBOX_2	92:96	NKENL	APC,CDC20,FZR1	0.5312	More...
Q9HAW4	Claspin	DEG_APCC_KENBOX_2	88:92	NKENL	APC,CDC20,FZR1	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons