DegronMD - Q8IYA6(CKAP2L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E196Q	TCGA-95-7947	LUAD	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.1111
p.P138H	TCGA-A2-A0YC	BRCA	TCGA	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.K185T	TCGA-A5-A0G2	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation altering degron motif	0.7306
p.I191N	TCGA-AN-A0AK	BRCA	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.25
p.N187S	TCGA-AP-A0LM	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation altering degron motif	0.7069
p.E194K	TCGA-AX-A0J0	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.1667
p.E174K	TCGA-BH-A0B7	BRCA	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.0556
p.E174K	TCGA-BR-8680	STAD	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.0556
p.D190N	TCGA-CA-6718	COAD	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.2778
p.D190N	SIDM01169	Ovarian Carcinoma	GDSC	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.2778
p.D190N	TOV-21G	ovary	COSMIC	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.2778
p.E186D	TCGA-E6-A1LX	UCEC	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation altering degron motif	0.6758
p.S128L	TCGA-EE-A2GI	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7667
p.N187K	TCGA-YL-A8HO	PRAD	TCGA	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation altering degron motif	0.6918
p.Y179C	DO3686	BRCA	ICGC	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.1944
p.R119W	DO49929	CESC	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation blocking ubiquitination signal	0.5833
p.V139A	DO227985	COCA	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0833
p.K128N	DO52089	HNSC	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6918
p.K128N	DO36394	READ	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6918
p.S193N	DO20835	KIRP	ICGC	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.1944
p.K191N	DO45360	LUAD	ICGC	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.25
p.Q190P	DO24729	LUAD	ICGC	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.2778
p.I197V	DO224605	LUSC	ICGC	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation rewiring degron network	0.0833
p.S127P	DO218962	PAAD	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6752
p.I186F	DO48550	SKCM	ICGC	NKENL	DEG_APCC_KENBOX_2	184:188	Mutation altering degron motif	0.7415
p.K133N	DO41235	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.25
p.G127E	SIDM00962	Chronic Myelogenous Leukemia	GDSC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6087
p.G127E	ACH-000432	Leukemia	CCLE	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6087
p.G127E	BV-173	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6087
p.C124S	SIDM00577	Neuroblastoma	GDSC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.2778
p.C124S	ACH-001603	Neuroblastoma	CCLE	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.2778
p.C124S	NH-12	autonomic ganglia	COSMIC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.2778
p.T130I	SIDM01617	Endometrial Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7078
p.T130I	ACH-000994	Endometrial/Uterine Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7078
p.L134R	SIDM01409	Bladder Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.2222
p.G127V	ACH-001131	Skin Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6421

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CKAP2L

UniProt ID: Q8IYA6

Entrez ID: 150468

Protein name: Cytoskeleton-associated protein 2-like (Radial fiber and mitotic spindle protein) (Radmis)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CKAP2L in