DegronMD

Uniprot ID: Q8IYA6

Source protein: Cytoskeleton-associated protein 2-like

Source gene: CKAP2L

Class: DEG_SPOP_SBC_1

Location: 126:130

E3 ligase: SPOP

DEGRON score: 0.9947

ASA_SCORE: 73.8

COIL: 0.9312

CONS_SCORE: 0.4098

DSS_SCORE: 0.5442

HELIX: 0.0438

FCONS_SCORE: 0.9506

RIG_SCORE: 0.5946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P138H	TCGA-A2-A0YC	BRCA	TCGA	AGSST	DEG_SPOP_SBC_1	0.1111
p.S128L	TCGA-EE-A2GI	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	0.7667
p.R119W	DO49929	CESC	ICGC	AGSST	DEG_SPOP_SBC_1	0.5833
p.V139A	DO227985	COCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.0833
p.K128N	DO52089	HNSC	ICGC	AGSST	DEG_SPOP_SBC_1	0.6918
p.K128N	DO36394	READ	ICGC	AGSST	DEG_SPOP_SBC_1	0.6918
p.S127P	DO218962	PAAD	ICGC	AGSST	DEG_SPOP_SBC_1	0.6752
p.K133N	DO41235	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	0.25
p.G127E	SIDM00962	Chronic Myelogenous Leukemia	GDSC	AGSST	DEG_SPOP_SBC_1	0.6087
p.G127E	ACH-000432	Leukemia	CCLE	AGSST	DEG_SPOP_SBC_1	0.6087
p.G127E	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	0.6087
p.C124S	SIDM00577	Neuroblastoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.2778
p.C124S	ACH-001603	Neuroblastoma	CCLE	AGSST	DEG_SPOP_SBC_1	0.2778
p.C124S	NH-12	autonomic_ganglia	COSMIC	AGSST	DEG_SPOP_SBC_1	0.2778
p.T130I	SIDM01617	Endometrial Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.7078
p.T130I	ACH-000994	Endometrial/Uterine Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.7078
p.L134R	SIDM01409	Bladder Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.2222
p.G127V	ACH-001131	Skin Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.6421

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14641	Segment polarity protein dishevelled homolog DVL-2	DEG_SPOP_SBC_1	2:6	AGSST	SPOP	0.8909	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	350:354	AGSST	SPOP	0.7056	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1419:1423	AGSST	SPOP	0.9595	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	998:1002	AGSST	SPOP	0.9876	More...
Q02952	A-kinase anchor protein 12	DEG_SPOP_SBC_1	3:7	AGSST	SPOP	0.9853	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	894:898	AGSST	SPOP	0.6443	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2885:2889	AGSST	SPOP	0.999	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.9947	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1091:1095	AGSST	SPOP	0.9949	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	526:530	AGSST	SPOP	0.9969	More...
Q9NRM1	Enamelin	DEG_SPOP_SBC_1	876:880	AGSST	SPOP	0.9743	More...
Q9UGH3	Solute carrier family 23 member 2	DEG_SPOP_SBC_1	15:19	AGSST	SPOP	0.9841	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.8436	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	728:732	AGSST	SPOP	0.6702	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	312:316	AGSST	SPOP	0.9799	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	40:44	AGSST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons