DegronMD

Uniprot ID: Q9NRM1

Source protein: Enamelin

Source gene: ENAM

Class: DEG_SPOP_SBC_1

Location: 876:880

E3 ligase: SPOP

DEGRON score: 0.9743

ASA_SCORE: 81.14

COIL: 0.963

CONS_SCORE: 0.8086

DSS_SCORE: 0.5211

HELIX: 0.0166

FCONS_SCORE: 0.8988

RIG_SCORE: 0.5887

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K883N	TCGA-E6-A1LX	UCEC	TCGA	AGSST	DEG_SPOP_SBC_1	0.3611
p.K883N	DO41020	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	0.3611
p.G881R	DO38404	STAD	ICGC	AGSST	DEG_SPOP_SBC_1	0.3056
p.G881E	SIDM00185	Melanoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.3056
p.G881E	ACH-002152	Skin Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.3056
p.G881E	LB2518-MEL	skin	COSMIC	AGSST	DEG_SPOP_SBC_1	0.3056
p.G881V	ACH-000872	Lung Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.3056
p.C875Y	ACH-001864	Bile Duct Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.3056
p.P882L	DO48197	ESCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.2778
p.S869R	TCGA-K4-A83P	BLCA	TCGA	AGSST	DEG_SPOP_SBC_1	0.1389
p.S869R	DO49787	BLCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.1389
p.H867Y	TCGA-W3-AA21	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	0.0833
p.H867Y	DO51278	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	0.0833

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.8436	More...
Q02952	A-kinase anchor protein 12	DEG_SPOP_SBC_1	3:7	AGSST	SPOP	0.9853	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	312:316	AGSST	SPOP	0.9799	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.9947	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2885:2889	AGSST	SPOP	0.999	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	728:732	AGSST	SPOP	0.6702	More...
Q9NRM1	Enamelin	DEG_SPOP_SBC_1	876:880	AGSST	SPOP	0.9743	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	350:354	AGSST	SPOP	0.7056	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1091:1095	AGSST	SPOP	0.9949	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	526:530	AGSST	SPOP	0.9969	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	998:1002	AGSST	SPOP	0.9876	More...
O14641	Segment polarity protein dishevelled homolog DVL-2	DEG_SPOP_SBC_1	2:6	AGSST	SPOP	0.8909	More...
Q9UGH3	Solute carrier family 23 member 2	DEG_SPOP_SBC_1	15:19	AGSST	SPOP	0.9841	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1419:1423	AGSST	SPOP	0.9595	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	40:44	AGSST	SPOP	0.9906	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	894:898	AGSST	SPOP	0.6443	More...

Showing 1 to 16 of 16 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons