DegronMD - Q9ULT6(ZNRF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S683L	TCGA-22-5491	LUSC	TCGA	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.3056
p.S683L	TCGA-DK-AA75	BLCA	TCGA	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.3056
p.G736W	TCGA-55-A490	LUAD	TCGA	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.2222
p.P678H	TCGA-D3-A1Q3	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.7694
p.P723S	TCGA-D3-A8GN	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1944
p.A725T	TCGA-DU-6392	LGG	TCGA	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.25
p.L687F	TCGA-FW-A3R5	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1944
p.S671F	TCGA-W3-AA1V	SKCM	TCGA	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1389
p.P678S	DO5521	BRCA	ICGC	PNSST	DEG_SPOP_SBC_1	678:682	Mutation altering degron motif	0.6752
p.G692R	DO230343	COCA	ICGC	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.0556
p.R689H	DO228041	EOPC	ICGC	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1389
p.K673R	DO233109	GACA	ICGC	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1944
p.R728H	DO233903	GACA	ICGC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.8244
p.R728C	DO228960	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.8301
p.R728C	DO42328	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.8301
p.V687M	DO229453	SKCA	ICGC	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1944
p.D737H	DO51750	STAD	ICGC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1944
p.E683A	DO222328	STAD	ICGC	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.3056
p.P718S	SIDM02034	Colorectal Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.0556
p.L733S	SIDM00845	Burkitt's Lymphoma	GDSC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.3056
p.L733S	Daudi	haematopoietic and lymphoid tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.3056
p.A728G	SIDM00301	Pancreatic Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.754
p.A728G	KP-4	pancreas	COSMIC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.754
p.L687R	SIDM00567	Other Solid Cancers	GDSC	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1944
p.L687R	ACH-000776	Brain Cancer	CCLE	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1944
p.L687R	ONS-76	central nervous system	COSMIC	PNSST	DEG_SPOP_SBC_1	678:682	Mutation rewiring degron network	0.1944
p.Y740C	SIDM00217	Colorectal Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.Y740C	ACH-000999	Colon/Colorectal Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.Y740C	SNU-1040	large intestine	COSMIC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.D739G	H2869	pleura	COSMIC	AGSST	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1389

Kaplan plot for ZNRF3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNRF3

UniProt ID: Q9ULT6

Entrez ID: 84133

Protein name: E3 ubiquitin-protein ligase ZNRF3 (EC 2.3.2.27) (RING finger protein 203) (RING-type E3 ubiquitin transferase ZNRF3) (Zinc/RING finger protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNRF3 in