DegronMD

Uniprot ID: Q9ULT6

Source protein: E3 ubiquitin-protein ligase ZNRF3

Source gene: ZNRF3

Class: DEG_SPOP_SBC_1

Location: 728:732

E3 ligase: SPOP

DEGRON score: 0.6702

ASA_SCORE: 63.62

COIL: 0.8082

CONS_SCORE: 0.2641

DSS_SCORE: 0.4878

HELIX: 0.1282

FCONS_SCORE: 0.921

RIG_SCORE: 0.6274

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G736W	TCGA-55-A490	LUAD	TCGA	AGSST	DEG_SPOP_SBC_1	0.2222
p.P723S	TCGA-D3-A8GN	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	0.1944
p.A725T	TCGA-DU-6392	LGG	TCGA	AGSST	DEG_SPOP_SBC_1	0.25
p.R728H	DO233903	GACA	ICGC	AGSST	DEG_SPOP_SBC_1	0.8244
p.R728C	DO228960	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	0.8301
p.R728C	DO42328	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	0.8301
p.D737H	DO51750	STAD	ICGC	AGSST	DEG_SPOP_SBC_1	0.1944
p.P718S	SIDM02034	Colorectal Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.0556
p.L733S	SIDM00845	Burkitt's Lymphoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.3056
p.L733S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AGSST	DEG_SPOP_SBC_1	0.3056
p.A728G	SIDM00301	Pancreatic Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.754
p.A728G	KP-4	pancreas	COSMIC	AGSST	DEG_SPOP_SBC_1	0.754
p.Y740C	SIDM00217	Colorectal Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.1111
p.Y740C	ACH-000999	Colon/Colorectal Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.1111
p.Y740C	SNU-1040	large_intestine	COSMIC	AGSST	DEG_SPOP_SBC_1	0.1111
p.D739G	H2869	pleura	COSMIC	AGSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14641	Segment polarity protein dishevelled homolog DVL-2	DEG_SPOP_SBC_1	2:6	AGSST	SPOP	0.8909	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	350:354	AGSST	SPOP	0.7056	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1419:1423	AGSST	SPOP	0.9595	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	998:1002	AGSST	SPOP	0.9876	More...
Q02952	A-kinase anchor protein 12	DEG_SPOP_SBC_1	3:7	AGSST	SPOP	0.9853	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	894:898	AGSST	SPOP	0.6443	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2885:2889	AGSST	SPOP	0.999	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.9947	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1091:1095	AGSST	SPOP	0.9949	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	526:530	AGSST	SPOP	0.9969	More...
Q9NRM1	Enamelin	DEG_SPOP_SBC_1	876:880	AGSST	SPOP	0.9743	More...
Q9UGH3	Solute carrier family 23 member 2	DEG_SPOP_SBC_1	15:19	AGSST	SPOP	0.9841	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.8436	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	728:732	AGSST	SPOP	0.6702	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	312:316	AGSST	SPOP	0.9799	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	40:44	AGSST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons