DegronMD - Q9NRM1(ENAM)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P814Q	TCGA-05-4396	LUAD	TCGA	NQPYYSNTP	CBL_PTK	806:814	Mutation altering degron motif	0.7035
p.P814Q	DO23838	LUAD	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation altering degron motif	0.7035
p.R211C	TCGA-14-2554	GBM	TCGA	PPYY	ITCH	212:215	Mutation rewiring degron network	0.3056
p.R211C	TCGA-A5-A0G2	UCEC	TCGA	PPYY	ITCH	212:215	Mutation rewiring degron network	0.3056
p.R211C	DO11202	GBM	ICGC	PPYY	ITCH	212:215	Mutation rewiring degron network	0.3056
p.R211C	DO41235	UCEC	ICGC	PPYY	ITCH	212:215	Mutation rewiring degron network	0.3056
p.P659S	TCGA-19-5956	GBM	TCGA	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1667
p.P659S	DO13863	GBM	ICGC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1667
p.P857T	TCGA-26-5134	GBM	TCGA	PPSY	ITCH	853:856	Mutation rewiring degron network	0.3056
p.P857T	TCGA-MP-A4TA	LUAD	TCGA	PPSY	ITCH	853:856	Mutation rewiring degron network	0.3056
p.P857T	DO12376	GBM	ICGC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.3056
p.P857T	DO45314	LUAD	ICGC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.3056
p.Q803K	TCGA-60-2714	LUSC	TCGA	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.25
p.Q803K	DO26530	LUSC	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.25
p.P797Q	TCGA-85-6560	LUSC	TCGA	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.0833
p.P797Q	DO26752	LUSC	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.0833
p.E968K	TCGA-90-A4ED	LUSC	TCGA	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.E968K	TCGA-EE-A2MD	SKCM	TCGA	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.E968K	DO45482	LUSC	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.E968K	DO222418	MELA	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.E968K	DO222434	MELA	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.E968K	DO229453	SKCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.E968K	DO218849	SKCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.E968K	DO37851	SKCM	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.E968K	SIDM01387	Small Cell Lung Carcinoma	GDSC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.E968K	ACH-000921	Lung Cancer	CCLE	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.S847Y	TCGA-AJ-A3EL	UCEC	TCGA	PPSY	ITCH	853:856	Mutation rewiring degron network	0.1667
p.S847Y	DO41542	UCEC	ICGC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.1667
p.T983A	TCGA-AO-A128	BRCA	TCGA	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.0833
p.T983A	TCGA-DI-A1BU	UCEC	TCGA	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.0833
p.T983A	DO5326	BRCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.0833
p.T983A	DO42023	UCEC	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.0833
p.D223G	TCGA-AX-A060	UCEC	TCGA	PPYY	ITCH	212:215	Mutation rewiring degron network	0.1111
p.D223G	DO42576	UCEC	ICGC	PPYY	ITCH	212:215	Mutation rewiring degron network	0.1111
p.K961N	TCGA-AX-A1CE	UCEC	TCGA	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation substituting flanking lysine	0.2222
p.K961N	DO42280	UCEC	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation substituting flanking lysine	0.2222
p.P854Q	TCGA-D3-A2JD	SKCM	TCGA	PPSY	ITCH	853:856	Mutation altering degron motif	0.7035
p.P854Q	DO37543	SKCM	ICGC	PPSY	ITCH	853:856	Mutation altering degron motif	0.7035
p.Q860E	TCGA-D8-A27G	BRCA	TCGA	PPSY	ITCH	853:856	Mutation rewiring degron network	0.2222
p.Q860E	DO5465	BRCA	ICGC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.2222
p.E862K	TCGA-DA-A1HY	SKCM	TCGA	PPSY	ITCH	853:856	Mutation rewiring degron network	0.1667
p.E862K	DO37409	SKCM	ICGC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.1667
p.G186E	TCGA-DA-A1I4	SKCM	TCGA	PPGY	ITCH	182:185	Mutation rewiring degron network	0.3056
p.G186E	DO37655	SKCM	ICGC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.3056
p.G805D	TCGA-DA-A3F8	SKCM	TCGA	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.3056
p.G805D	DO37418	SKCM	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.3056
p.S959Y	TCGA-DK-A6AW	BLCA	TCGA	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.0556
p.S959Y	DO48566	BLCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.0556
p.S976T	TCGA-E2-A14W	BRCA	TCGA	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2778
p.S976T	DO4281	BRCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2778
p.K883N	TCGA-E6-A1LX	UCEC	TCGA	AGSST	DEG_SPOP_SBC_1	876:880	Mutation substituting flanking lysine	0.3611
p.K883N	DO41020	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	876:880	Mutation substituting flanking lysine	0.3611
p.E193K	TCGA-EE-A3J4	SKCM	TCGA	PPGY	ITCH	182:185	Mutation rewiring degron network	0.1111
p.E193K	TCGA-FR-A726	SKCM	TCGA	PPGY	ITCH	182:185	Mutation rewiring degron network	0.1111
p.E193K	DO48665	SKCM	ICGC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.1111
p.E193K	DO48604	SKCM	ICGC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.1111
p.N850K	TCGA-EO-A22U	UCEC	TCGA	PPSY	ITCH	853:856	Mutation rewiring degron network	0.25
p.N850K	DO43755	UCEC	ICGC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.25
p.P800L	TCGA-ER-A19Q	SKCM	TCGA	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.1667
p.P800L	DO47497	SKCM	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.1667
p.P808L	TCGA-EY-A1GI	UCEC	TCGA	NQPYYSNTP	CBL_PTK	806:814	Mutation altering degron motif	0.6471
p.P808L	DO41211	UCEC	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation altering degron motif	0.6471
p.P814L	TCGA-F4-6808	COAD	TCGA	NQPYYSNTP	CBL_PTK	806:814	Mutation altering degron motif	0.7582
p.P814L	DO8946	COAD	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation altering degron motif	0.7582
p.Q818R	TCGA-FI-A2F4	UCEC	TCGA	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.2222
p.Q818R	DO43434	UCEC	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.2222
p.P849S	TCGA-FR-A726	SKCM	TCGA	PPSY	ITCH	853:856	Mutation rewiring degron network	0.2222
p.P849S	DO48665	SKCM	ICGC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.2222
p.E647K	TCGA-FW-A3R5	SKCM	TCGA	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.3056
p.E647K	DO37406	SKCM	ICGC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.3056
p.E647K	SIDM00383	Gastric Carcinoma	GDSC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.3056
p.E647K	ACH-002198	Gastric Cancer	CCLE	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.3056
p.E647K	SCH	stomach	COSMIC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.3056
p.D644N	TCGA-HD-A633	HNSC	TCGA	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.2222
p.D644N	DO49061	HNSC	ICGC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.2222
p.P814T	TCGA-HE-7129	KIRP	TCGA	NQPYYSNTP	CBL_PTK	806:814	Mutation altering degron motif	0.7031
p.P814T	DO20786	KIRP	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation altering degron motif	0.7031
p.Q966H	TCGA-IB-7651	PAAD	TCGA	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.25
p.Q966H	DO46657	PAAD	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.25
p.S869R	TCGA-K4-A83P	BLCA	TCGA	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1389
p.S869R	DO49787	BLCA	ICGC	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.1389
p.G210S	TCGA-W3-AA1O	SKCM	TCGA	PPYY	ITCH	212:215	Mutation rewiring degron network	0.2778
p.G210S	DO51274	SKCM	ICGC	PPYY	ITCH	212:215	Mutation rewiring degron network	0.2778
p.H867Y	TCGA-W3-AA21	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0833
p.H867Y	DO51278	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.0833
p.D658N	TCGA-WE-AAA3	SKCM	TCGA	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1944
p.D658N	DO51295	SKCM	ICGC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1944
p.K967N	TCGA-YD-A9TA	SKCM	TCGA	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2778
p.K967N	DO219503	SKCM	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2778
p.I822M	DO230310	COCA	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.1111
p.I648T	DO227999	COCA	ICGC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation altering degron motif	0.7078
p.I648T	DO229005	COCA	ICGC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation altering degron motif	0.7078
p.A975V	DO222762	COCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.3056
p.A798D	DO234256	ESAD	ICGC	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.1111
p.P882L	DO48197	ESCA	ICGC	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.2778
p.E221G	DO233103	GACA	ICGC	PPYY	ITCH	212:215	Mutation rewiring degron network	0.1667
p.E221G	DO233791	GACA	ICGC	PPYY	ITCH	212:215	Mutation rewiring degron network	0.1667
p.G859V	DO229019	LICA	ICGC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.25
p.G859V	SIDM01619	Endometrial Carcinoma	GDSC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.25
p.G859V	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	853:856	Mutation rewiring degron network	0.25
p.R187L	DO229032	LICA	ICGC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.2778
p.W174C	DO229031	LICA	ICGC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.1111
p.K981N	DO23088	LINC	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation substituting flanking lysine	0.25
p.P177L	DO23388	LINC	ICGC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.1944
p.S191I	DO48715	LIRI	ICGC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.1667
p.P213L	DO220900	MELA	ICGC	PPYY	ITCH	212:215	Mutation altering degron motif	0.7582
p.P639S	DO222384	MELA	ICGC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.0833
p.P639S	ACH-001522	Skin Cancer	CCLE	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.0833
p.S977F	DO229465	SKCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.25
p.G881R	DO38404	STAD	ICGC	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056
p.E663Q	SIDM02038	Colorectal Carcinoma	GDSC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.0556
p.R843S	SIDM01034	B-Lymphoblastic Leukemia	GDSC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.0556
p.R843S	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.0556
p.R843S	SIDM00572	Gastric Carcinoma	GDSC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.0556
p.R843S	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.0556
p.R843S	SIDM00324	Neuroblastoma	GDSC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.0556
p.R843S	SIDM01442	Glioma	GDSC	PPSY	ITCH	853:856	Mutation rewiring degron network	0.0556
p.G881E	SIDM00185	Melanoma	GDSC	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056
p.G881E	ACH-002152	Skin Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056
p.G881E	LB2518-MEL	skin	COSMIC	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056
p.L978I	SIDM00789	Colorectal Carcinoma	GDSC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2222
p.L978I	ACH-000997	Colon/Colorectal Cancer	CCLE	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2222
p.L978I	ACH-001061	Colon/Colorectal Cancer	CCLE	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2222
p.L978I	HCT-15	large intestine	COSMIC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2222
p.G195V	SIDM00475	Ovarian Carcinoma	GDSC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.0556
p.N641D	SIDM00151	Ovarian Carcinoma	GDSC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1389
p.N641D	ACH-000966	Ovarian Cancer	CCLE	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1389
p.N641D	IGROV-1	ovary	COSMIC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1389
p.L978P	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2222
p.L978P	ACH-001642	Lymphoma	CCLE	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2222
p.L978P	SCC-3	haematopoietic and lymphoid tissue	COSMIC	IMPFPE	LIG_APCC_ABBA_1	969:974	Mutation rewiring degron network	0.2222
p.G186A	SIDM00143	Small Cell Lung Carcinoma	GDSC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.3056
p.G186A	ACH-000803	Lung Cancer	CCLE	PPGY	ITCH	182:185	Mutation rewiring degron network	0.3056
p.G186A	COLO-668	lung	COSMIC	PPGY	ITCH	182:185	Mutation rewiring degron network	0.3056
p.I640V	SIDM00640	Mesothelioma	GDSC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1111
p.I640V	ACH-000335	Lung Cancer	CCLE	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1111
p.I640V	MSTO-211H	pleura	COSMIC	IVPYNE	LIG_APCC_ABBA_1	648:653	Mutation rewiring degron network	0.1111
p.P801L	SIDM00150	Colorectal Carcinoma	GDSC	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.1944
p.P801L	ACH-000969	Colon/Colorectal Cancer	CCLE	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.1944
p.P801L	KM12	large intestine	COSMIC	NQPYYSNTP	CBL_PTK	806:814	Mutation rewiring degron network	0.1944
p.G881V	ACH-000872	Lung Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056
p.C875Y	ACH-001864	Bile Duct Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	876:880	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ENAM

UniProt ID: Q9NRM1

Entrez ID: 10117

Protein name: Enamelin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ENAM in