Degron: NQPYYSNTP
      
      
      
        
          
            
              
              
                
                
                  Enamelin                
              
              
                
                ENAM
              
              
              
                
                806:814
              
              
                
                CBL
              
              
                
                0.9936
              
               
              
              
                
                95.6333
              
              
                
                0.9481
              
              
                
                0.7351
              
              
                
                0.6759
              
              
                
                0.0264
              
              
                
                1.1755
              
              
              
                
                0.6564
              
              
              
              
            
           
         
        
        
          
        Degron related mutations and impact score
        
                
 
                 
                      
                        
                          | Mutation | 
                          Sample | 
                          Cancer | 
                          Dataset | 
                          Degron | 
                          Degron class | 
                          Impact score | 
                        
                      
                      
                           | p.P814Q | TCGA-05-4396 | LUAD | TCGA | NQPYYSNTP | CBL_PTK | 0.7035 | 
| p.P814Q | DO23838 | LUAD | ICGC | NQPYYSNTP | CBL_PTK | 0.7035 | 
| p.Q803K | TCGA-60-2714 | LUSC | TCGA | NQPYYSNTP | CBL_PTK | 0.25 | 
| p.Q803K | DO26530 | LUSC | ICGC | NQPYYSNTP | CBL_PTK | 0.25 | 
| p.P797Q | TCGA-85-6560 | LUSC | TCGA | NQPYYSNTP | CBL_PTK | 0.0833 | 
| p.P797Q | DO26752 | LUSC | ICGC | NQPYYSNTP | CBL_PTK | 0.0833 | 
| p.G805D | TCGA-DA-A3F8 | SKCM | TCGA | NQPYYSNTP | CBL_PTK | 0.3056 | 
| p.G805D | DO37418 | SKCM | ICGC | NQPYYSNTP | CBL_PTK | 0.3056 | 
| p.P800L | TCGA-ER-A19Q | SKCM | TCGA | NQPYYSNTP | CBL_PTK | 0.1667 | 
| p.P800L | DO47497 | SKCM | ICGC | NQPYYSNTP | CBL_PTK | 0.1667 | 
| p.P808L | TCGA-EY-A1GI | UCEC | TCGA | NQPYYSNTP | CBL_PTK | 0.6471 | 
| p.P808L | DO41211 | UCEC | ICGC | NQPYYSNTP | CBL_PTK | 0.6471 | 
| p.P814L | TCGA-F4-6808 | COAD | TCGA | NQPYYSNTP | CBL_PTK | 0.7582 | 
| p.P814L | DO8946 | COAD | ICGC | NQPYYSNTP | CBL_PTK | 0.7582 | 
| p.Q818R | TCGA-FI-A2F4 | UCEC | TCGA | NQPYYSNTP | CBL_PTK | 0.2222 | 
| p.Q818R | DO43434 | UCEC | ICGC | NQPYYSNTP | CBL_PTK | 0.2222 | 
| p.P814T | TCGA-HE-7129 | KIRP | TCGA | NQPYYSNTP | CBL_PTK | 0.7031 | 
| p.P814T | DO20786 | KIRP | ICGC | NQPYYSNTP | CBL_PTK | 0.7031 | 
| p.I822M | DO230310 | COCA | ICGC | NQPYYSNTP | CBL_PTK | 0.1111 | 
| p.A798D | DO234256 | ESAD | ICGC | NQPYYSNTP | CBL_PTK | 0.1111 | 
| p.P801L | SIDM00150 | Colorectal Carcinoma | GDSC | NQPYYSNTP | CBL_PTK | 0.1944 | 
| p.P801L | ACH-000969 | Colon/Colorectal Cancer | CCLE | NQPYYSNTP | CBL_PTK | 0.1944 | 
| p.P801L | KM12 | large_intestine | COSMIC | NQPYYSNTP | CBL_PTK | 0.1944 | 
                      
                    
                  
           
          
        
        Drug responses associated with ENAM mutations        
        
                
                  
                  
                    
                      
                      
                      | Sample | 
                      Cancer | 
                      Mutation (In Degron?) | 
                      Dataset | 
                      Drug | 
                      IC50 | 
                    
                  
                  
                                      
                
                  
           
        
        All proteins holding degron of  NQPYYSNTP
        
                
                  
                  
                    
                      | Uniprot ID | 
                      Source protein | 
                      Degron class | 
                      Location | 
                      Hit | 
                      E3 ligase | 
                      Degron score | 
                      Detail | 
                    
                  
                  
                    | Q9NRM1 | Enamelin | CBL_PTK | 806:814 | NQPYYSNTP | CBL | 0.9936 | More... |