DegronMD

Uniprot ID: Q9NRM1

Source protein: Enamelin

Source gene: ENAM

Class: LIG_APCC_ABBA_1

Location: 648:653

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9767

ASA_SCORE: 106.9667

COIL: 0.9437

CONS_SCORE: 0.8558

DSS_SCORE: 0.7572

HELIX: 0.0335

FCONS_SCORE: 1.0964

RIG_SCORE: 0.7187

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P659S	TCGA-19-5956	GBM	TCGA	IVPYNE	LIG_APCC_ABBA_1	0.1667
p.P659S	DO13863	GBM	ICGC	IVPYNE	LIG_APCC_ABBA_1	0.1667
p.E647K	TCGA-FW-A3R5	SKCM	TCGA	IVPYNE	LIG_APCC_ABBA_1	0.3056
p.E647K	DO37406	SKCM	ICGC	IVPYNE	LIG_APCC_ABBA_1	0.3056
p.E647K	SIDM00383	Gastric Carcinoma	GDSC	IVPYNE	LIG_APCC_ABBA_1	0.3056
p.E647K	ACH-002198	Gastric Cancer	CCLE	IVPYNE	LIG_APCC_ABBA_1	0.3056
p.E647K	SCH	stomach	COSMIC	IVPYNE	LIG_APCC_ABBA_1	0.3056
p.D644N	TCGA-HD-A633	HNSC	TCGA	IVPYNE	LIG_APCC_ABBA_1	0.2222
p.D644N	DO49061	HNSC	ICGC	IVPYNE	LIG_APCC_ABBA_1	0.2222
p.D658N	TCGA-WE-AAA3	SKCM	TCGA	IVPYNE	LIG_APCC_ABBA_1	0.1944
p.D658N	DO51295	SKCM	ICGC	IVPYNE	LIG_APCC_ABBA_1	0.1944
p.I648T	DO227999	COCA	ICGC	IVPYNE	LIG_APCC_ABBA_1	0.7078
p.I648T	DO229005	COCA	ICGC	IVPYNE	LIG_APCC_ABBA_1	0.7078
p.P639S	DO222384	MELA	ICGC	IVPYNE	LIG_APCC_ABBA_1	0.0833
p.P639S	ACH-001522	Skin Cancer	CCLE	IVPYNE	LIG_APCC_ABBA_1	0.0833
p.E663Q	SIDM02038	Colorectal Carcinoma	GDSC	IVPYNE	LIG_APCC_ABBA_1	0.0556
p.N641D	SIDM00151	Ovarian Carcinoma	GDSC	IVPYNE	LIG_APCC_ABBA_1	0.1389
p.N641D	ACH-000966	Ovarian Cancer	CCLE	IVPYNE	LIG_APCC_ABBA_1	0.1389
p.N641D	IGROV-1	ovary	COSMIC	IVPYNE	LIG_APCC_ABBA_1	0.1389
p.I640V	SIDM00640	Mesothelioma	GDSC	IVPYNE	LIG_APCC_ABBA_1	0.1111
p.I640V	ACH-000335	Lung Cancer	CCLE	IVPYNE	LIG_APCC_ABBA_1	0.1111
p.I640V	MSTO-211H	pleura	COSMIC	IVPYNE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRM1	Enamelin	LIG_APCC_ABBA_1	648:653	IVPYNE	APC,CDC20,FZR1	0.9767	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons