DegronMD

Uniprot ID: Q9NRM1

Source protein: Enamelin

Source gene: ENAM

Class: LIG_APCC_ABBA_1

Location: 969:974

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9642

ASA_SCORE: 98.5167

COIL: 0.9305

CONS_SCORE: 0.706

DSS_SCORE: 0.5836

HELIX: 0.033

FCONS_SCORE: 0.9182

RIG_SCORE: 0.7462

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E968K	TCGA-90-A4ED	LUSC	TCGA	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.E968K	TCGA-EE-A2MD	SKCM	TCGA	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.E968K	DO45482	LUSC	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.E968K	DO222418	MELA	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.E968K	DO222434	MELA	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.E968K	DO229453	SKCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.E968K	DO218849	SKCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.E968K	DO37851	SKCM	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.E968K	SIDM01387	Small Cell Lung Carcinoma	GDSC	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.E968K	ACH-000921	Lung Cancer	CCLE	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.T983A	TCGA-AO-A128	BRCA	TCGA	IMPFPE	LIG_APCC_ABBA_1	0.0833
p.T983A	TCGA-DI-A1BU	UCEC	TCGA	IMPFPE	LIG_APCC_ABBA_1	0.0833
p.T983A	DO5326	BRCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.0833
p.T983A	DO42023	UCEC	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.0833
p.K961N	TCGA-AX-A1CE	UCEC	TCGA	IMPFPE	LIG_APCC_ABBA_1	0.2222
p.K961N	DO42280	UCEC	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.2222
p.S959Y	TCGA-DK-A6AW	BLCA	TCGA	IMPFPE	LIG_APCC_ABBA_1	0.0556
p.S959Y	DO48566	BLCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.0556
p.S976T	TCGA-E2-A14W	BRCA	TCGA	IMPFPE	LIG_APCC_ABBA_1	0.2778
p.S976T	DO4281	BRCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.2778
p.Q966H	TCGA-IB-7651	PAAD	TCGA	IMPFPE	LIG_APCC_ABBA_1	0.25
p.Q966H	DO46657	PAAD	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.25
p.K967N	TCGA-YD-A9TA	SKCM	TCGA	IMPFPE	LIG_APCC_ABBA_1	0.2778
p.K967N	DO219503	SKCM	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.2778
p.A975V	DO222762	COCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.3056
p.K981N	DO23088	LINC	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.25
p.S977F	DO229465	SKCA	ICGC	IMPFPE	LIG_APCC_ABBA_1	0.25
p.L978I	SIDM00789	Colorectal Carcinoma	GDSC	IMPFPE	LIG_APCC_ABBA_1	0.2222
p.L978I	ACH-000997	Colon/Colorectal Cancer	CCLE	IMPFPE	LIG_APCC_ABBA_1	0.2222
p.L978I	ACH-001061	Colon/Colorectal Cancer	CCLE	IMPFPE	LIG_APCC_ABBA_1	0.2222
p.L978I	HCT-15	large_intestine	COSMIC	IMPFPE	LIG_APCC_ABBA_1	0.2222
p.L978P	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	IMPFPE	LIG_APCC_ABBA_1	0.2222
p.L978P	ACH-001642	Lymphoma	CCLE	IMPFPE	LIG_APCC_ABBA_1	0.2222
p.L978P	SCC-3	haematopoietic_and_lymphoid_tissue	COSMIC	IMPFPE	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IMPFPE

Degron related mutations and impact score

Drug responses associated with ENAM mutations

All proteins holding degron of IMPFPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRM1	Enamelin	LIG_APCC_ABBA_1	969:974	IMPFPE	APC,CDC20,FZR1	0.9642	More...