DegronMD - Q02952(AKAP12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1038L	TCGA-18-3416	LUSC	TCGA	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.1667
p.E605K	TCGA-3C-AALI	BRCA	TCGA	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.2778
p.V1029I	TCGA-AA-3821	COAD	TCGA	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation altering degron motif	0.7076
p.D541Y	TCGA-AX-A05Z	UCEC	TCGA	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation altering degron motif	0.7325
p.R622C	TCGA-CD-A48C	STAD	TCGA	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.0556
p.T608N	TCGA-DC-4745	READ	TCGA	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation altering degron motif	0.8166
p.P609L	TCGA-EE-A29V	SKCM	TCGA	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation altering degron motif	0.7582
p.P551Q	TCGA-EE-A2MD	SKCM	TCGA	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.1944
p.P1021L	TCGA-EO-A22U	UCEC	TCGA	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.25
p.S554Y	TCGA-EO-A3B0	UCEC	TCGA	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation blocking phosphorylation signal	0.5556
p.R622S	TCGA-EU-5906	KIRC	TCGA	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.0556
p.P555S	TCGA-FD-A43X	BLCA	TCGA	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.0833
p.Q549E	TCGA-FD-A62O	BLCA	TCGA	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.25
p.P555L	TCGA-FS-A4FD	SKCM	TCGA	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.0833
p.D599N	TCGA-VS-A8EL	CESC	TCGA	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.1111
p.G605E	DO526	BLCA	ICGC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.2778
p.V9A	DO224593	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2778
p.V9A	DO1020	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2778
p.D617N	DO4780	BRCA	ICGC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.1944
p.D612E	DO5326	BRCA	ICGC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation altering degron motif	0.6758
p.V533D	DO4185	BRCA	ICGC	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.1111
p.G613E	DO8490	COAD	ICGC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.3056
p.E8K	DO50446	ESAD	ICGC	AGSST	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.3056
p.E8K	ACH-001207	Non-Cancerous	CCLE	AGSST	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.3056
p.G3R	DO233941	GACA	ICGC	AGSST	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7568
p.E1037K	DO22237	LGG	ICGC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.1944
p.E1037K	DO41020	UCEC	ICGC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.1944
p.E1033Q	DO23678	LUAD	ICGC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.3056
p.P1026L	DO220878	MELA	ICGC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation altering degron motif	0.7582
p.E617D	DO232761	PBCA	ICGC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.1944
p.A545D	DO47159	RECA	ICGC	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation altering degron motif	0.7793
p.E15K	DO229502	SKCA	ICGC	AGSST	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1111
p.E1023D	DO37643	SKCM	ICGC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.3056
p.G611R	DO37404	SKCM	ICGC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation altering degron motif	0.7568
p.P1019H	DO37491	SKCM	ICGC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.1944
p.S14F	DO51267	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1389
p.A543T	DO38192	STAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation altering degron motif	0.7139
p.G597W	DO48177	UCEC	ICGC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation blocking phosphorylation signal	0.5
p.G597W	SNG-M	endometrium	COSMIC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation blocking phosphorylation signal	0.5
p.D621N	DO223277	UCEC	ICGC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation substituting flanking lysine	0.1944
p.T1039A	DO41379	UCEC	ICGC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation blocking phosphorylation signal	0.5833
p.Q1040L	SIDM00935	Other Solid Cancers	GDSC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.1111
p.Q1040L	CAL-39	vulva	COSMIC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.1111
p.D599E	SIDM00075	Non-Cancerous	GDSC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.1111
p.D599E	ACH-002336	Unknown	CCLE	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation rewiring degron network	0.1111
p.R1038W	SIDM00482	Chronic Myelogenous Leukemia	GDSC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.1667
p.R1038W	SIDM01229	Neuroblastoma	GDSC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.1667
p.T1039I	SIDM00516	Melanoma	GDSC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation blocking phosphorylation signal	0.5833
p.T1039I	ACH-002166	Skin Cancer	CCLE	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation blocking phosphorylation signal	0.5833
p.T1039I	MZ7-mel	skin	COSMIC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation blocking phosphorylation signal	0.5833
p.Q533H	SIDM00534	Colorectal Carcinoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.1111
p.Q533H	ACH-000986	Colon/Colorectal Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.1111
p.Q533H	HT-115	large intestine	COSMIC	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.1111
p.P609S	SIDM01322	Oral Cavity Carcinoma	GDSC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation altering degron motif	0.6752
p.P609S	ACH-000735	Head and Neck Cancer	CCLE	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation altering degron motif	0.6752
p.R1038Q	SIDM01695	Acute Myeloid Leukemia	GDSC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.1667
p.R537I	SIDM01611	Endometrial Carcinoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.2222
p.R537I	ACH-000996	Endometrial/Uterine Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.2222
p.S554F	SIDM01588	Endometrial Carcinoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation blocking phosphorylation signal	0.5556
p.S554F	ACH-000993	Endometrial/Uterine Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation blocking phosphorylation signal	0.5556
p.Q14P	ACH-000647	Esophageal Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1389
p.S6A	ACH-000851	Lung Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.87
p.Q549R	ACH-000948	Gastric Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.25
p.Q549R	23132-87	stomach	COSMIC	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.25
p.D16E	LCLC-97TM1	lung	COSMIC	AGSST	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0833
p.V1042I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation rewiring degron network	0.0556
p.T618M	NCC021	kidney	COSMIC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation blocking phosphorylation signal	0.6111
p.T618M	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation blocking phosphorylation signal	0.6111
p.M552I	HCC2998	large intestine	COSMIC	DEESGE	DEG_Kelch_Keap1_1	541:546	Mutation rewiring degron network	0.1667
p.S1024N	KM12	large intestine	COSMIC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation altering degron motif	0.7069
p.S1031N	KM12	large intestine	COSMIC	EVEGGVPDI	DEG_COP1_1	1024:1032	Mutation altering degron motif	0.7069
p.E618D	SAT	upper aerodigestive tract	COSMIC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation blocking phosphorylation signal	0.6111
p.E611D	SAT	upper aerodigestive tract	COSMIC	VTPWAS	DEG_SCF_FBW7_1	607:612	Mutation altering degron motif	0.6758

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP12

UniProt ID: Q02952

Entrez ID: 9590

Protein name: A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP12 in