DegronMD

Uniprot ID: Q02952

Source protein: A-kinase anchor protein 12

Source gene: AKAP12

Class: DEG_SCF_FBW7_1

Location: 607:612

E3 ligase: FBXW7

DEGRON score: 0.9889

ASA_SCORE: 80.5833

COIL: 0.7418

CONS_SCORE: 0.8564

DSS_SCORE: 0.5535

HELIX: 0.1355

FCONS_SCORE: 0.9205

RIG_SCORE: 0.7254

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E605K	TCGA-3C-AALI	BRCA	TCGA	VTPWAS	DEG_SCF_FBW7_1	0.2778
p.R622C	TCGA-CD-A48C	STAD	TCGA	VTPWAS	DEG_SCF_FBW7_1	0.0556
p.T608N	TCGA-DC-4745	READ	TCGA	VTPWAS	DEG_SCF_FBW7_1	0.8166
p.P609L	TCGA-EE-A29V	SKCM	TCGA	VTPWAS	DEG_SCF_FBW7_1	0.7582
p.R622S	TCGA-EU-5906	KIRC	TCGA	VTPWAS	DEG_SCF_FBW7_1	0.0556
p.D599N	TCGA-VS-A8EL	CESC	TCGA	VTPWAS	DEG_SCF_FBW7_1	0.1111
p.G605E	DO526	BLCA	ICGC	VTPWAS	DEG_SCF_FBW7_1	0.2778
p.D617N	DO4780	BRCA	ICGC	VTPWAS	DEG_SCF_FBW7_1	0.1944
p.D612E	DO5326	BRCA	ICGC	VTPWAS	DEG_SCF_FBW7_1	0.6758
p.G613E	DO8490	COAD	ICGC	VTPWAS	DEG_SCF_FBW7_1	0.3056
p.E617D	DO232761	PBCA	ICGC	VTPWAS	DEG_SCF_FBW7_1	0.1944
p.G611R	DO37404	SKCM	ICGC	VTPWAS	DEG_SCF_FBW7_1	0.7568
p.G597W	DO48177	UCEC	ICGC	VTPWAS	DEG_SCF_FBW7_1	0.5
p.G597W	SNG-M	endometrium	COSMIC	VTPWAS	DEG_SCF_FBW7_1	0.5
p.D621N	DO223277	UCEC	ICGC	VTPWAS	DEG_SCF_FBW7_1	0.1944
p.D599E	SIDM00075	Non-Cancerous	GDSC	VTPWAS	DEG_SCF_FBW7_1	0.1111
p.D599E	ACH-002336	Unknown	CCLE	VTPWAS	DEG_SCF_FBW7_1	0.1111
p.P609S	SIDM01322	Oral Cavity Carcinoma	GDSC	VTPWAS	DEG_SCF_FBW7_1	0.6752
p.P609S	ACH-000735	Head and Neck Cancer	CCLE	VTPWAS	DEG_SCF_FBW7_1	0.6752
p.T618M	NCC021	kidney	COSMIC	VTPWAS	DEG_SCF_FBW7_1	0.6111
p.T618M	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	VTPWAS	DEG_SCF_FBW7_1	0.6111
p.E618D	SAT	upper_aerodigestive_tract	COSMIC	VTPWAS	DEG_SCF_FBW7_1	0.6111
p.E611D	SAT	upper_aerodigestive_tract	COSMIC	VTPWAS	DEG_SCF_FBW7_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02952	A-kinase anchor protein 12	DEG_SCF_FBW7_1	607:612	VTPWAS	FBXW7	0.9889	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons