DegronMD

Uniprot ID: Q02952

Source protein: A-kinase anchor protein 12

Source gene: AKAP12

Class: DEG_SPOP_SBC_1

Location: 3:7

E3 ligase: SPOP

DEGRON score: 0.9853

ASA_SCORE: 88.02

COIL: 0.9594

CONS_SCORE: 0.7276

DSS_SCORE: 0.9941

HELIX: 0.0166

FCONS_SCORE: 1.1009

RIG_SCORE: 0.5255

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V9A	DO224593	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.2778
p.V9A	DO1020	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.2778
p.E8K	DO50446	ESAD	ICGC	AGSST	DEG_SPOP_SBC_1	0.3056
p.E8K	ACH-001207	Non-Cancerous	CCLE	AGSST	DEG_SPOP_SBC_1	0.3056
p.G3R	DO233941	GACA	ICGC	AGSST	DEG_SPOP_SBC_1	0.7568
p.E15K	DO229502	SKCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.1111
p.S14F	DO51267	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	0.1389
p.Q14P	ACH-000647	Esophageal Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.1389
p.S6A	ACH-000851	Lung Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.87
p.D16E	LCLC-97TM1	lung	COSMIC	AGSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14641	Segment polarity protein dishevelled homolog DVL-2	DEG_SPOP_SBC_1	2:6	AGSST	SPOP	0.8909	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	350:354	AGSST	SPOP	0.7056	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1419:1423	AGSST	SPOP	0.9595	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	998:1002	AGSST	SPOP	0.9876	More...
Q02952	A-kinase anchor protein 12	DEG_SPOP_SBC_1	3:7	AGSST	SPOP	0.9853	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	894:898	AGSST	SPOP	0.6443	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2885:2889	AGSST	SPOP	0.999	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.9947	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1091:1095	AGSST	SPOP	0.9949	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	526:530	AGSST	SPOP	0.9969	More...
Q9NRM1	Enamelin	DEG_SPOP_SBC_1	876:880	AGSST	SPOP	0.9743	More...
Q9UGH3	Solute carrier family 23 member 2	DEG_SPOP_SBC_1	15:19	AGSST	SPOP	0.9841	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.8436	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	728:732	AGSST	SPOP	0.6702	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	312:316	AGSST	SPOP	0.9799	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	40:44	AGSST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons