DegronMD

Uniprot ID: Q7Z6Z7

Source protein: E3 ubiquitin-protein ligase HUWE1

Source gene: HUWE1

Class: DEG_SPOP_SBC_1

Location: 2885:2889

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 75.66

COIL: 0.9586

CONS_SCORE: 0.3454

DSS_SCORE: 0.8205

HELIX: 0.0186

FCONS_SCORE: 1.0902

RIG_SCORE: 0.5086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2882H	TCGA-97-7938	LUAD	TCGA	AGSST	DEG_SPOP_SBC_1	0.25
p.Q2882H	DO24329	LUAD	ICGC	AGSST	DEG_SPOP_SBC_1	0.25
p.E2881K	TCGA-JW-A5VL	CESC	TCGA	AGSST	DEG_SPOP_SBC_1	0.2222
p.E2881K	DO49976	CESC	ICGC	AGSST	DEG_SPOP_SBC_1	0.2222
p.T2889N	DO225319	BRCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.8166
p.P2895Q	DO223368	CLLE	ICGC	AGSST	DEG_SPOP_SBC_1	0.1667
p.P2883L	DO229221	THCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.2778
p.P2895L	ACH-001369	Ovarian Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.1667
p.R2894S	KLE	endometrium	COSMIC	AGSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14641	Segment polarity protein dishevelled homolog DVL-2	DEG_SPOP_SBC_1	2:6	AGSST	SPOP	0.8909	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	350:354	AGSST	SPOP	0.7056	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1419:1423	AGSST	SPOP	0.9595	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	998:1002	AGSST	SPOP	0.9876	More...
Q02952	A-kinase anchor protein 12	DEG_SPOP_SBC_1	3:7	AGSST	SPOP	0.9853	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	894:898	AGSST	SPOP	0.6443	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2885:2889	AGSST	SPOP	0.999	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.9947	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1091:1095	AGSST	SPOP	0.9949	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	526:530	AGSST	SPOP	0.9969	More...
Q9NRM1	Enamelin	DEG_SPOP_SBC_1	876:880	AGSST	SPOP	0.9743	More...
Q9UGH3	Solute carrier family 23 member 2	DEG_SPOP_SBC_1	15:19	AGSST	SPOP	0.9841	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.8436	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	728:732	AGSST	SPOP	0.6702	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	312:316	AGSST	SPOP	0.9799	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	40:44	AGSST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons