DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 1091:1095

E3 ligase: SPOP

DEGRON score: 0.9949

ASA_SCORE: 76.06

COIL: 0.9606

CONS_SCORE: 0

DSS_SCORE: 0.613

HELIX: 0.0146

FCONS_SCORE: 0

RIG_SCORE: 0.5612

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1084Q	TCGA-91-6835	LUAD	TCGA	AGSST	DEG_SPOP_SBC_1	0.1389
p.P1084Q	DO26082	LUAD	ICGC	AGSST	DEG_SPOP_SBC_1	0.1389
p.S1083F	TCGA-CA-6718	COAD	TCGA	AGSST	DEG_SPOP_SBC_1	0.1111
p.S1083F	DO7801	COAD	ICGC	AGSST	DEG_SPOP_SBC_1	0.1111
p.S1083F	SIDM00680	Colorectal Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.1111
p.S1083F	ACH-000957	Colon/Colorectal Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.1111
p.S1083F	LS-180	large_intestine	COSMIC	AGSST	DEG_SPOP_SBC_1	0.1111
p.S1083Y	TCGA-E6-A1LX	UCEC	TCGA	AGSST	DEG_SPOP_SBC_1	0.1111
p.S1083Y	DO41020	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	0.1111
p.P1084L	TCGA-EE-A2M5	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	0.1389
p.P1084L	DO222423	MELA	ICGC	AGSST	DEG_SPOP_SBC_1	0.1389
p.P1084L	DO37425	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	0.1389
p.V1103I	TCGA-XU-A92Z	THYM	TCGA	AGSST	DEG_SPOP_SBC_1	0.1111
p.V1103A	DO231527	LINC	ICGC	AGSST	DEG_SPOP_SBC_1	0.1111
p.G1097E	DO222843	MELA	ICGC	AGSST	DEG_SPOP_SBC_1	0.2778
p.S1094N	DO36556	READ	ICGC	AGSST	DEG_SPOP_SBC_1	0.7069
p.R1098K	DO229470	SKCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.25
p.V1082I	SIDM02050	Colorectal Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.0833
p.Q1086K	SIDM00935	Other Solid Cancers	GDSC	AGSST	DEG_SPOP_SBC_1	0.1944
p.Q1086K	ACH-002091	Skin Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.1944
p.Q1086K	CAL-39	vulva	COSMIC	AGSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14641	Segment polarity protein dishevelled homolog DVL-2	DEG_SPOP_SBC_1	2:6	AGSST	SPOP	0.8909	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	350:354	AGSST	SPOP	0.7056	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1419:1423	AGSST	SPOP	0.9595	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	998:1002	AGSST	SPOP	0.9876	More...
Q02952	A-kinase anchor protein 12	DEG_SPOP_SBC_1	3:7	AGSST	SPOP	0.9853	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	894:898	AGSST	SPOP	0.6443	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2885:2889	AGSST	SPOP	0.999	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.9947	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1091:1095	AGSST	SPOP	0.9949	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	526:530	AGSST	SPOP	0.9969	More...
Q9NRM1	Enamelin	DEG_SPOP_SBC_1	876:880	AGSST	SPOP	0.9743	More...
Q9UGH3	Solute carrier family 23 member 2	DEG_SPOP_SBC_1	15:19	AGSST	SPOP	0.9841	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.8436	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	728:732	AGSST	SPOP	0.6702	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	312:316	AGSST	SPOP	0.9799	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	40:44	AGSST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons