DegronMD - Q9UGI9(PRKAG3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D120Y	TCGA-33-4566	LUSC	TCGA	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1667
p.D120Y	DO26790	LUSC	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1667
p.R48I	TCGA-AA-A00N	COAD	TCGA	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.25
p.R48I	DO9876	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.25
p.I49L	TCGA-AP-A0LM	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.I49L	DO43306	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.2222
p.A8T	TCGA-CD-A4MI	STAD	TCGA	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.A8T	DO47717	STAD	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.S128C	TCGA-CQ-5333	HNSC	TCGA	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7541
p.R10H	TCGA-D1-A103	UCEC	TCGA	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7133
p.R10H	DO42312	UCEC	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7133
p.A55V	TCGA-DF-A2KU	UCEC	TCGA	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0556
p.A55V	DO223286	UCEC	ICGC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.0556
p.G20S	TCGA-EE-A2A2	SKCM	TCGA	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.G20S	TCGA-ER-A1A1	SKCM	TCGA	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.G20S	DO37583	SKCM	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.G20S	DO37413	SKCM	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.R48K	TCGA-EE-A2GD	SKCM	TCGA	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.25
p.R48K	DO37603	SKCM	ICGC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.25
p.E134K	TCGA-FS-A1Z3	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.2222
p.E134K	DO37635	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.2222
p.L18I	DO48429	BLCA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2778
p.F53V	DO8264	COAD	ICGC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1111
p.L116P	DO227906	COCA	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0556
p.P129L	DO10880	GBM	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7582
p.L35M	DO50458	KIRC	ICGC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1667
p.T12N	DO228985	LICA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7055
p.W46R	DO23192	LINC	ICGC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.3056
p.A12D	DO231102	LUSC	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.7793
p.S17Y	DO26701	LUSC	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.3056
p.E6Q	DO232858	NACA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.25
p.M26I	DO46792	PRAD	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.0556
p.Q5H	DO228014	SKCA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.E6K	DO228014	SKCA	ICGC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.25
p.N119S	DO50301	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1389
p.L138I	DO37946	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.1111
p.L127I	DO43041	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.7174
p.R50H	SIDM01016	T-Lymphoblastic Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1944
p.R50H	SIDM01263	T-Lymphoblastic Leukemia	GDSC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1944
p.R50H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1944
p.G20A	SIDM00455	Pancreatic Carcinoma	GDSC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.G20A	ACH-000599	Pancreatic Cancer	CCLE	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.G20A	PA-TU-8902	pancreas	COSMIC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation rewiring degron network	0.2222
p.L9M	SIDM00942	Oral Cavity Carcinoma	GDSC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.5999
p.L9M	ACH-000518	Head and Neck Cancer	CCLE	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.5999
p.L9M	CAL-33	upper aerodigestive tract	COSMIC	LRRTPSWS	DEG_SCF_FBW7_1	9:16	Mutation altering degron motif	0.5999
p.S36L	SIDM00562	Breast Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1944
p.S36L	ACH-002163	Breast Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1944
p.G51R	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1667
p.G51R	ACH-000886	Lung Cancer	CCLE	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1667
p.G51R	NCI-H2009	lung	COSMIC	AVTSS	DEG_SPOP_SBC_1	41:45	Mutation rewiring degron network	0.1667
p.G127V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6421
p.G127V	ACH-000951	Lung Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6421
p.G127V	NCI-H2342	lung	COSMIC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation altering degron motif	0.6421
p.F139L	SIDM01526	Mesothelioma	GDSC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0833
p.F139L	SIDM01588	Endometrial Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	126:130	Mutation rewiring degron network	0.0833

Kaplan plot for PRKAG3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRKAG3

UniProt ID: Q9UGI9

Entrez ID: 53632

Protein name: 5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PRKAG3 in