DegronMD

Uniprot ID: Q9UGI9

Source protein: 5'-AMP-activated protein kinase subunit gamma-3

Source gene: PRKAG3

Class: DEG_SPOP_SBC_1

Location: 126:130

E3 ligase: SPOP

DEGRON score: 0.8436

ASA_SCORE: 65.2

COIL: 0.8882

CONS_SCORE: 0.197

DSS_SCORE: 0.4796

HELIX: 0.0854

FCONS_SCORE: 0.9755

RIG_SCORE: 0.6525

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D120Y	TCGA-33-4566	LUSC	TCGA	AGSST	DEG_SPOP_SBC_1	0.1667
p.D120Y	DO26790	LUSC	ICGC	AGSST	DEG_SPOP_SBC_1	0.1667
p.S128C	TCGA-CQ-5333	HNSC	TCGA	AGSST	DEG_SPOP_SBC_1	0.7541
p.E134K	TCGA-FS-A1Z3	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	0.2222
p.E134K	DO37635	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	0.2222
p.L116P	DO227906	COCA	ICGC	AGSST	DEG_SPOP_SBC_1	0.0556
p.P129L	DO10880	GBM	ICGC	AGSST	DEG_SPOP_SBC_1	0.7582
p.N119S	DO50301	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	0.1389
p.L138I	DO37946	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	0.1111
p.L127I	DO43041	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	0.7174
p.G127V	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.6421
p.G127V	ACH-000951	Lung Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	0.6421
p.G127V	NCI-H2342	lung	COSMIC	AGSST	DEG_SPOP_SBC_1	0.6421
p.F139L	SIDM01526	Mesothelioma	GDSC	AGSST	DEG_SPOP_SBC_1	0.0833
p.F139L	SIDM01588	Endometrial Carcinoma	GDSC	AGSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14641	Segment polarity protein dishevelled homolog DVL-2	DEG_SPOP_SBC_1	2:6	AGSST	SPOP	0.8909	More...
P08235	Mineralocorticoid receptor	DEG_SPOP_SBC_1	350:354	AGSST	SPOP	0.7056	More...
P51532	Transcription activator BRG1	DEG_SPOP_SBC_1	1419:1423	AGSST	SPOP	0.9595	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	998:1002	AGSST	SPOP	0.9876	More...
Q02952	A-kinase anchor protein 12	DEG_SPOP_SBC_1	3:7	AGSST	SPOP	0.9853	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	894:898	AGSST	SPOP	0.6443	More...
Q7Z6Z7	E3 ubiquitin-protein ligase HUWE1	DEG_SPOP_SBC_1	2885:2889	AGSST	SPOP	0.999	More...
Q8IYA6	Cytoskeleton-associated protein 2-like	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.9947	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1091:1095	AGSST	SPOP	0.9949	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	526:530	AGSST	SPOP	0.9969	More...
Q9NRM1	Enamelin	DEG_SPOP_SBC_1	876:880	AGSST	SPOP	0.9743	More...
Q9UGH3	Solute carrier family 23 member 2	DEG_SPOP_SBC_1	15:19	AGSST	SPOP	0.9841	More...
Q9UGI9	5'-AMP-activated protein kinase subunit gamma-3	DEG_SPOP_SBC_1	126:130	AGSST	SPOP	0.8436	More...
Q9ULT6	E3 ubiquitin-protein ligase ZNRF3	DEG_SPOP_SBC_1	728:732	AGSST	SPOP	0.6702	More...
O75808	Calpain-15	DEG_SPOP_SBC_1	312:316	AGSST	SPOP	0.9799	More...
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SPOP_SBC_1	40:44	AGSST	SPOP	0.9906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons