DegronMD - Q6ZVL6(KIAA1549L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V688A	TCGA-06-5416	GBM	TCGA	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1111
p.V688A	DO10880	GBM	ICGC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1111
p.T612N	TCGA-44-2656	LUAD	TCGA	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7055
p.T612N	DO26052	LUAD	ICGC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7055
p.S666R	TCGA-49-6743	LUAD	TCGA	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation blocking phosphorylation signal	0.5
p.S666R	DO26092	LUAD	ICGC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation blocking phosphorylation signal	0.5
p.A40S	TCGA-49-AAR9	LUAD	TCGA	AGSST	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.7588
p.A40S	DO218921	LUAD	ICGC	AGSST	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.7588
p.R615K	TCGA-92-8065	LUSC	TCGA	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.3056
p.R615K	DO27074	LUSC	ICGC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.3056
p.T1724N	TCGA-A5-A0G2	UCEC	TCGA	IPTPPSS	DEG_SCF_FBW7_1	1728:1734	Mutation rewiring degron network	0.2222
p.T1724N	DO41235	UCEC	ICGC	IPTPPSS	DEG_SCF_FBW7_1	1728:1734	Mutation rewiring degron network	0.2222
p.G46V	TCGA-AA-3875	COAD	TCGA	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.2778
p.G46V	DO9282	COAD	ICGC	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.2778
p.T683I	TCGA-AP-A1DV	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.25
p.T683I	DO43186	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.25
p.P610L	TCGA-AX-A05Z	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7582
p.P610L	TCGA-YG-AA3N	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7582
p.P610L	DO51298	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7582
p.P610L	DO40884	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.7582
p.T689R	TCGA-B0-4827	KIRC	TCGA	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.0833
p.T689R	DO16158	KIRC	ICGC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.0833
p.A672V	TCGA-B5-A11E	UCEC	TCGA	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2222
p.A672V	DO41644	UCEC	ICGC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.2222
p.P1732L	TCGA-B5-A1MX	UCEC	TCGA	IPTPPSS	DEG_SCF_FBW7_1	1728:1734	Mutation altering degron motif	0.6471
p.P1732L	DO41999	UCEC	ICGC	IPTPPSS	DEG_SCF_FBW7_1	1728:1734	Mutation altering degron motif	0.6471
p.P623S	TCGA-BF-A5EO	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.0833
p.P623S	DO219450	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.0833
p.S605W	TCGA-D9-A6EC	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation blocking phosphorylation signal	0.6389
p.S605W	DO50291	SKCM	ICGC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation blocking phosphorylation signal	0.6389
p.T1730M	TCGA-EO-A22U	UCEC	TCGA	IPTPPSS	DEG_SCF_FBW7_1	1728:1734	Mutation altering degron motif	0.7423
p.T1730M	DO43755	UCEC	ICGC	IPTPPSS	DEG_SCF_FBW7_1	1728:1734	Mutation altering degron motif	0.7423
p.E35D	TCGA-ER-A19B	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1944
p.E35D	DO47491	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1944
p.R611S	TCGA-F5-6814	READ	TCGA	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.6316
p.R611S	DO36556	READ	ICGC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation altering degron motif	0.6316
p.S678R	TCGA-OL-A66P	BRCA	TCGA	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7427
p.S678R	DO44182	BRCA	ICGC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7427
p.P45S	TCGA-W3-A824	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.3056
p.P45S	DO51271	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.3056
p.M51V	DO222576	COCA	ICGC	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1389
p.I604V	DO229010	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.1667
p.T34P	DO50323	ESAD	ICGC	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1667
p.K686R	DO10858	ESAD	ICGC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation substituting flanking lysine	0.2778
p.P33R	DO228825	LICA	ICGC	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1389
p.G1725V	DO229028	LICA	ICGC	IPTPPSS	DEG_SCF_FBW7_1	1728:1734	Mutation rewiring degron network	0.25
p.S607N	DO222908	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.25
p.A670T	DO232224	PBCA	ICGC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation rewiring degron network	0.1667
p.S680L	SIDM00193	Colorectal Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7667
p.S680L	SIDM00596	Endometrial Carcinoma	GDSC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7667
p.S680L	ACH-000941	Endometrial/Uterine Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7667
p.S680L	ACH-000954	Endometrial/Uterine Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7667
p.S680L	ACH-000991	Colon/Colorectal Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7667
p.S680L	ACH-001517	Endometrial/Uterine Cancer	CCLE	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7667
p.S680L	SNU-81	large intestine	COSMIC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7667
p.S680L	HEC-1	endometrium	COSMIC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation altering degron motif	0.7667
p.R618Q	SIDM00650	Small Cell Lung Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.R618Q	SIDM00907	Burkitt's Lymphoma	GDSC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.R618Q	SIDM01681	Non-Cancerous	GDSC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.R618Q	SIDM01173	Rhabdomyosarcoma	GDSC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.2222
p.Q621E	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.1389
p.Q621E	ACH-000841	Lung Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.1389
p.Q621E	NCI-H2087	lung	COSMIC	PRTSS	DEG_SPOP_SBC_1	610:614	Mutation rewiring degron network	0.1389
p.P45H	ACH-001518	Endometrial/Uterine Cancer	CCLE	AGSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.3056
p.S686L	HEC-1	endometrium	COSMIC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation substituting flanking lysine	0.2778
p.S686L	SNU-81	large intestine	COSMIC	AKSSS	DEG_SPOP_SBC_1	676:680	Mutation substituting flanking lysine	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA1549L

UniProt ID: Q6ZVL6

Entrez ID: 25758

Protein name: UPF0606 protein KIAA1549L

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIAA1549L in