DegronMD

Uniprot ID: Q6ZVL6

Source protein: UPF0606 protein KIAA1549L

Source gene: KIAA1549L

Class: DEG_SCF_FBW7_1

Location: 1728:1734

E3 ligase: FBXW7

DEGRON score: 0.9515

ASA_SCORE: 55.2429

COIL: 0.8297

CONS_SCORE: 0.3925

DSS_SCORE: 0.2786

HELIX: 0.0391

FCONS_SCORE: 0.9173

RIG_SCORE: 0.7478

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1724N	TCGA-A5-A0G2	UCEC	TCGA	IPTPPSS	DEG_SCF_FBW7_1	0.2222
p.T1724N	DO41235	UCEC	ICGC	IPTPPSS	DEG_SCF_FBW7_1	0.2222
p.P1732L	TCGA-B5-A1MX	UCEC	TCGA	IPTPPSS	DEG_SCF_FBW7_1	0.6471
p.P1732L	DO41999	UCEC	ICGC	IPTPPSS	DEG_SCF_FBW7_1	0.6471
p.T1730M	TCGA-EO-A22U	UCEC	TCGA	IPTPPSS	DEG_SCF_FBW7_1	0.7423
p.T1730M	DO43755	UCEC	ICGC	IPTPPSS	DEG_SCF_FBW7_1	0.7423
p.G1725V	DO229028	LICA	ICGC	IPTPPSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZVL6	UPF0606 protein KIAA1549L	DEG_SCF_FBW7_1	1728:1734	IPTPPSS	FBXW7	0.9515	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons