DegronMD - Q68DK2(ZFYVE26)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q910H	TCGA-37-4130	LUSC	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation altering degron motif	0.647
p.Q910H	DO26490	LUSC	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation altering degron motif	0.647
p.Q910H	SIDM00839	Colorectal Carcinoma	GDSC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation altering degron motif	0.647
p.Q910H	ACH-000950	Colon/Colorectal Cancer	CCLE	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation altering degron motif	0.647
p.Q910H	LoVo	large intestine	COSMIC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation altering degron motif	0.647
p.A915S	TCGA-55-A4DG	LUAD	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.2778
p.A915S	DO26337	LUAD	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.2778
p.G919R	TCGA-A5-A0G2	UCEC	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.1667
p.G919R	DO41235	UCEC	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.1667
p.Q910K	TCGA-A5-A0GM	UCEC	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation altering degron motif	0.5833
p.Q910K	DO42737	UCEC	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation altering degron motif	0.5833
p.A894V	TCGA-AX-A2HC	UCEC	TCGA	AGSST	DEG_SPOP_SBC_1	894:898	Mutation altering degron motif	0.5825
p.A894V	DO41572	UCEC	ICGC	AGSST	DEG_SPOP_SBC_1	894:898	Mutation altering degron motif	0.5825
p.T1301S	TCGA-AZ-4315	COAD	TCGA	ALTSS	DEG_SPOP_SBC_1	1299:1303	Mutation altering degron motif	0.6005
p.T1301S	DO8842	COAD	ICGC	ALTSS	DEG_SPOP_SBC_1	1299:1303	Mutation altering degron motif	0.6005
p.Q1117K	TCGA-D3-A2JN	SKCM	TCGA	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation rewiring degron network	0.1111
p.Q1117K	DO47590	SKCM	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation rewiring degron network	0.1111
p.A1097V	TCGA-DU-6392	LGG	TCGA	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation rewiring degron network	0.1667
p.A1097V	DO22237	LGG	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation rewiring degron network	0.1667
p.R901I	TCGA-F5-6814	READ	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.2222
p.R901I	TCGA-F5-6814	READ	TCGA	AGSST	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.25
p.R901I	DO36556	READ	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.2222
p.R901I	DO36556	READ	ICGC	AGSST	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.25
p.A1115T	TCGA-FI-A2D5	UCEC	TCGA	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation rewiring degron network	0.1667
p.A1115T	DO41331	UCEC	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation rewiring degron network	0.1667
p.P1106S	TCGA-FR-A726	SKCM	TCGA	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation altering degron motif	0.6752
p.P1106S	DO48665	SKCM	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation altering degron motif	0.6752
p.A917V	TCGA-MN-A4N4	LUAD	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.2222
p.A917V	DO26250	LUAD	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.2222
p.R900W	TCGA-Z2-A8RT	SKCM	TCGA	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.1944
p.R900W	TCGA-Z2-A8RT	SKCM	TCGA	AGSST	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.2778
p.R900W	DO51301	SKCM	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.1944
p.R900W	DO51301	SKCM	ICGC	AGSST	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.2778
p.P1103L	DO229003	COCA	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation altering degron motif	0.6471
p.P1103L	DO223144	ESCA	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation altering degron motif	0.6471
p.P1103L	DO230659	LAML	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation altering degron motif	0.6471
p.P1103L	DO52365	LUSC	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation altering degron motif	0.6471
p.Y1289S	DO228643	GACA	ICGC	ALTSS	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.0556
p.A916E	DO229045	LICA	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.25
p.S1110F	DO220899	MELA	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation rewiring degron network	0.3056
p.S1291F	DO219872	SKCA	ICGC	ALTSS	DEG_SPOP_SBC_1	1299:1303	Mutation blocking phosphorylation signal	0.5556
p.A918V	DO229259	THCA	ICGC	GRSTLQAIG	DEG_APCC_DBOX_1	905:913	Mutation rewiring degron network	0.1944
p.R1104M	DO229240	THCA	ICGC	PRTPPLS	DEG_SCF_FBW7_1	1103:1109	Mutation altering degron motif	0.7521
p.R1311C	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.1111
p.R1311C	ACH-000912	Lung Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.1111
p.P1292S	ACH-000774	Lung Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	1299:1303	Mutation rewiring degron network	0.1389
p.E884D	ACH-002261	Neuroblastoma	CCLE	AGSST	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.0556
p.E884D	KP-N-YS	autonomic ganglia	COSMIC	AGSST	DEG_SPOP_SBC_1	894:898	Mutation rewiring degron network	0.0556

Kaplan plot for ZFYVE26 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZFYVE26

UniProt ID: Q68DK2

Entrez ID: 23503

Protein name: Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZFYVE26 in