DegronMD

Uniprot ID: Q68DK2

Source protein: Zinc finger FYVE domain-containing protein 26

Source gene: ZFYVE26

Class: DEG_SPOP_SBC_1

Location: 1299:1303

E3 ligase: SPOP

DEGRON score: 0.9456

ASA_SCORE: 59.98

COIL: 0.5446

CONS_SCORE: 0.3501

DSS_SCORE: 0.3601

HELIX: 0.4276

FCONS_SCORE: 0.9691

RIG_SCORE: 0.7411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1301S	TCGA-AZ-4315	COAD	TCGA	ALTSS	DEG_SPOP_SBC_1	0.6005
p.T1301S	DO8842	COAD	ICGC	ALTSS	DEG_SPOP_SBC_1	0.6005
p.Y1289S	DO228643	GACA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.0556
p.S1291F	DO219872	SKCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.5556
p.R1311C	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.1111
p.R1311C	ACH-000912	Lung Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.1111
p.P1292S	ACH-000774	Lung Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	288:292	ALTSS	SPOP	0.9872	More...
P40305	Interferon alpha-inducible protein 27, mitochondrial	DEG_SPOP_SBC_1	5:9	ALTSS	SPOP	0.8417	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	37:41	ALTSS	SPOP	0.9991	More...
Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	DEG_SPOP_SBC_1	385:389	ALTSS	SPOP	0.7353	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	1299:1303	ALTSS	SPOP	0.9456	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	182:186	ALTSS	SPOP	0.8556	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	382:386	ALTSS	SPOP	0.8748	More...
Q9NZ09	Ubiquitin-associated protein 1	DEG_SPOP_SBC_1	334:338	ALTSS	SPOP	0.9693	More...
Q6TFL3	Coiled-coil domain-containing protein 171	DEG_SPOP_SBC_1	1303:1307	ALTSS	SPOP	0.6534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons