DegronMD

Uniprot ID: P49736

Source protein: DNA replication licensing factor MCM2

Source gene: MCM2

Class: DEG_SPOP_SBC_1

Location: 37:41

E3 ligase: SPOP

DEGRON score: 0.9991

ASA_SCORE: 81.04

COIL: 0.938

CONS_SCORE: 0.2105

DSS_SCORE: 0.7985

HELIX: 0.0522

FCONS_SCORE: 1.0436

RIG_SCORE: 0.5698

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S40P	TCGA-13-0886	OV	TCGA	ALTSS	DEG_SPOP_SBC_1	0.7863
p.S40P	DO30250	OV	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7863
p.L38I	TCGA-AU-6004	COAD	TCGA	ALTSS	DEG_SPOP_SBC_1	0.6063
p.L38I	DO7780	COAD	ICGC	ALTSS	DEG_SPOP_SBC_1	0.6063
p.D36N	TCGA-UY-A9PH	BLCA	TCGA	ALTSS	DEG_SPOP_SBC_1	0.3056
p.D36N	DO223594	BLCA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.3056
p.R33Q	DO228947	LICA	ICGC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R33Q	SIDM00425	Ovarian Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R33Q	SIDM01194	Hepatocellular Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R33Q	SIDM00350	Head and Neck Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R33Q	SIDM01093	Cervical Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R33Q	SIDM00358	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R33Q	SIDM00359	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R44G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.25
p.R44G	ACH-000983	Leukemia	CCLE	ALTSS	DEG_SPOP_SBC_1	0.25
p.R44G	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.25
p.S40F	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.9093
p.S40F	ACH-000983	Leukemia	CCLE	ALTSS	DEG_SPOP_SBC_1	0.9093
p.S40F	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.9093
p.T39I	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.8189
p.T39I	NCI-H661	lung	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.8189
p.P42L	SIDM00878	Breast Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.3056
p.P42L	ACH-000930	Breast Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.3056
p.P42L	HCC1569	breast	COSMIC	ALTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	288:292	ALTSS	SPOP	0.9872	More...
P40305	Interferon alpha-inducible protein 27, mitochondrial	DEG_SPOP_SBC_1	5:9	ALTSS	SPOP	0.8417	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	37:41	ALTSS	SPOP	0.9991	More...
Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	DEG_SPOP_SBC_1	385:389	ALTSS	SPOP	0.7353	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	1299:1303	ALTSS	SPOP	0.9456	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	182:186	ALTSS	SPOP	0.8556	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	382:386	ALTSS	SPOP	0.8748	More...
Q9NZ09	Ubiquitin-associated protein 1	DEG_SPOP_SBC_1	334:338	ALTSS	SPOP	0.9693	More...
Q6TFL3	Coiled-coil domain-containing protein 171	DEG_SPOP_SBC_1	1303:1307	ALTSS	SPOP	0.6534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons