DegronMD

Uniprot ID: Q96P56

Source protein: Cation channel sperm-associated protein 2

Source gene: CATSPER2

Class: DEG_SPOP_SBC_1

Location: 382:386

E3 ligase: SPOP

DEGRON score: 0.8748

ASA_SCORE: 64.98

COIL: 0.4446

CONS_SCORE: 0.3684

DSS_SCORE: 0.6347

HELIX: 0.5374

FCONS_SCORE: 0.9934

RIG_SCORE: 0.6287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T384M	TCGA-A5-A0G2	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.7423
p.T384M	TCGA-A5-A1OF	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.7423
p.T384M	TCGA-D1-A103	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.7423
p.T384M	DO42312	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7423
p.T384M	DO42568	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7423
p.T384M	DO41235	UCEC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.7423
p.R395I	TCGA-B5-A1MR	UCEC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.0833
p.S394L	TCGA-D3-A3MR	SKCM	TCGA	ALTSS	DEG_SPOP_SBC_1	0.1111
p.E381K	TCGA-VS-A9UC	CESC	TCGA	ALTSS	DEG_SPOP_SBC_1	0.3056
p.E381K	DO219732	CESC	ICGC	ALTSS	DEG_SPOP_SBC_1	0.3056
p.A382V	DO10858	ESAD	ICGC	ALTSS	DEG_SPOP_SBC_1	0.5825
p.T390M	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.T390M	SIDM00657	Acute Myeloid Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.T390M	SIDM01398	Melanoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.T390M	SIDM01660	Kidney Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2222
p.R380S	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	0.2778
p.S385T	ACH-001061	Colon/Colorectal Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	288:292	ALTSS	SPOP	0.9872	More...
P40305	Interferon alpha-inducible protein 27, mitochondrial	DEG_SPOP_SBC_1	5:9	ALTSS	SPOP	0.8417	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	37:41	ALTSS	SPOP	0.9991	More...
Q5JS13	Ras-specific guanine nucleotide-releasing factor RalGPS1	DEG_SPOP_SBC_1	385:389	ALTSS	SPOP	0.7353	More...
Q68DK2	Zinc finger FYVE domain-containing protein 26	DEG_SPOP_SBC_1	1299:1303	ALTSS	SPOP	0.9456	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	182:186	ALTSS	SPOP	0.8556	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	382:386	ALTSS	SPOP	0.8748	More...
Q9NZ09	Ubiquitin-associated protein 1	DEG_SPOP_SBC_1	334:338	ALTSS	SPOP	0.9693	More...
Q6TFL3	Coiled-coil domain-containing protein 171	DEG_SPOP_SBC_1	1303:1307	ALTSS	SPOP	0.6534	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons