DegronMD - P49736(MCM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D51H	TCGA-05-4427	LUAD	TCGA	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.7688
p.D51H	DO23666	LUAD	ICGC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.7688
p.G76S	TCGA-06-0184	GBM	TCGA	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.2222
p.G76S	DO12496	GBM	ICGC	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.2222
p.R18W	TCGA-06-5416	GBM	TCGA	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18W	DO10880	GBM	ICGC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.S40P	TCGA-13-0886	OV	TCGA	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.7863
p.S40P	DO30250	OV	ICGC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.7863
p.D51Y	TCGA-18-3416	LUSC	TCGA	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.7325
p.D51Y	DO26423	LUSC	ICGC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.7325
p.L38I	TCGA-AU-6004	COAD	TCGA	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.6063
p.L38I	DO7780	COAD	ICGC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.6063
p.D22G	TCGA-AX-A1CE	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.D22G	DO42280	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.E50D	TCGA-EO-A22R	UCEC	TCGA	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.5647
p.E50D	DO229025	LICA	ICGC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.5647
p.E50D	DO42713	UCEC	ICGC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation altering degron motif	0.5647
p.D36N	TCGA-UY-A9PH	BLCA	TCGA	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0833
p.D36N	TCGA-UY-A9PH	BLCA	TCGA	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.D36N	TCGA-UY-A9PH	BLCA	TCGA	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.0556
p.D36N	DO223594	BLCA	ICGC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0833
p.D36N	DO223594	BLCA	ICGC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.D36N	DO223594	BLCA	ICGC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.0556
p.E91K	TCGA-XF-A8HG	BLCA	TCGA	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.0833
p.E91K	DO49802	BLCA	ICGC	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.0833
p.G76V	TCGA-ZX-AA5X	CESC	TCGA	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.2222
p.G76V	DO219762	CESC	ICGC	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.2222
p.A89V	DO8730	COAD	ICGC	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.1389
p.I73V	DO228554	GACA	ICGC	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.1389
p.R18P	DO229346	LAML	ICGC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM00353	Other Sarcomas	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM00411	Pancreatic Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM00535	Chondrosarcoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM00619	Thyroid Gland Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM00596	Endometrial Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM00997	Thyroid Gland Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM01511	Gastric Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM01336	Glioblastoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM01446	Glioblastoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R18P	SIDM01443	Gastric Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R33Q	DO228947	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.R33Q	DO228947	LICA	ICGC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.R33Q	SIDM00425	Ovarian Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.R33Q	SIDM00425	Ovarian Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.R33Q	SIDM01194	Hepatocellular Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.R33Q	SIDM01194	Hepatocellular Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.R33Q	SIDM00350	Head and Neck Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.R33Q	SIDM00350	Head and Neck Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.R33Q	SIDM01093	Cervical Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.R33Q	SIDM01093	Cervical Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.R33Q	SIDM00358	Gastric Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.R33Q	SIDM00358	Gastric Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.R33Q	SIDM00359	Colorectal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1667
p.R33Q	SIDM00359	Colorectal Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.2222
p.G58V	DO229019	LICA	ICGC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.1389
p.G58V	DO231026	LUSC	ICGC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.1389
p.E71D	DO229035	LICA	ICGC	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.0833
p.S53F	DO220877	MELA	ICGC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation blocking phosphorylation signal	0.7222
p.R82H	DO232761	PBCA	ICGC	DYR	CBL_MET	80:82	Mutation altering degron motif	0.8244
p.R44G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.25
p.R44G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.2778
p.R44G	ACH-000983	Leukemia	CCLE	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.25
p.R44G	ACH-000983	Leukemia	CCLE	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.2778
p.R44G	KCL-22	haematopoietic and lymphoid tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.25
p.R44G	KCL-22	haematopoietic and lymphoid tissue	COSMIC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.2778
p.S40F	SIDM01004	Chronic Myelogenous Leukemia	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.9093
p.S40F	ACH-000983	Leukemia	CCLE	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.9093
p.S40F	KCL-22	haematopoietic and lymphoid tissue	COSMIC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.9093
p.E52Q	SIDM01174	Cervical Carcinoma	GDSC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.3056
p.E52Q	ACH-001402	Cervical Cancer	CCLE	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.3056
p.E52Q	SW756	cervix	COSMIC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.3056
p.D22Y	SIDM00367	Small Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.D22Y	ACH-002197	Lung Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.D22Y	SBC-3	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.T39I	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.8189
p.T39I	NCI-H661	lung	COSMIC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation altering degron motif	0.8189
p.P42L	SIDM00878	Breast Carcinoma	GDSC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.P42L	SIDM00878	Breast Carcinoma	GDSC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.2222
p.P42L	ACH-000930	Breast Cancer	CCLE	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.P42L	ACH-000930	Breast Cancer	CCLE	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.2222
p.P42L	HCC1569	breast	COSMIC	ALTSS	DEG_SPOP_SBC_1	37:41	Mutation rewiring degron network	0.3056
p.P42L	HCC1569	breast	COSMIC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.2222
p.T25A	SIDM01045	Endometrial Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.825
p.T25A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.825
p.T25A	EN	endometrium	COSMIC	PLTSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.825
p.G76D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.2222
p.G76D	ACH-001127	Leukemia	CCLE	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.2222
p.G76D	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	80:82	Mutation rewiring degron network	0.2222
p.G61E	SIDM00225	Melanoma	GDSC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.0556
p.G61E	ACH-002143	Skin Cancer	CCLE	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.0556
p.G61E	IST-MEL1	skin	COSMIC	LPPFED	LIG_APCC_ABBA_1	46:51	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MCM2

UniProt ID: P49736

Entrez ID: 4171

Protein name: DNA replication licensing factor MCM2 (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MCM2 in