DegronMD

Uniprot ID: P49736

Source protein: DNA replication licensing factor MCM2

Source gene: MCM2

Class: LIG_APCC_ABBA_1

Location: 46:51

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9989

ASA_SCORE: 74.0167

COIL: 0.8177

CONS_SCORE: 0.2271

DSS_SCORE: 0.8142

HELIX: 0.1483

FCONS_SCORE: 1.0716

RIG_SCORE: 0.644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D51H	TCGA-05-4427	LUAD	TCGA	LPPFED	LIG_APCC_ABBA_1	0.7688
p.D51H	DO23666	LUAD	ICGC	LPPFED	LIG_APCC_ABBA_1	0.7688
p.D51Y	TCGA-18-3416	LUSC	TCGA	LPPFED	LIG_APCC_ABBA_1	0.7325
p.D51Y	DO26423	LUSC	ICGC	LPPFED	LIG_APCC_ABBA_1	0.7325
p.E50D	TCGA-EO-A22R	UCEC	TCGA	LPPFED	LIG_APCC_ABBA_1	0.5647
p.E50D	DO229025	LICA	ICGC	LPPFED	LIG_APCC_ABBA_1	0.5647
p.E50D	DO42713	UCEC	ICGC	LPPFED	LIG_APCC_ABBA_1	0.5647
p.D36N	TCGA-UY-A9PH	BLCA	TCGA	LPPFED	LIG_APCC_ABBA_1	0.0556
p.D36N	DO223594	BLCA	ICGC	LPPFED	LIG_APCC_ABBA_1	0.0556
p.G58V	DO229019	LICA	ICGC	LPPFED	LIG_APCC_ABBA_1	0.1389
p.G58V	DO231026	LUSC	ICGC	LPPFED	LIG_APCC_ABBA_1	0.1389
p.S53F	DO220877	MELA	ICGC	LPPFED	LIG_APCC_ABBA_1	0.7222
p.R44G	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LPPFED	LIG_APCC_ABBA_1	0.2778
p.R44G	ACH-000983	Leukemia	CCLE	LPPFED	LIG_APCC_ABBA_1	0.2778
p.R44G	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LPPFED	LIG_APCC_ABBA_1	0.2778
p.E52Q	SIDM01174	Cervical Carcinoma	GDSC	LPPFED	LIG_APCC_ABBA_1	0.3056
p.E52Q	ACH-001402	Cervical Cancer	CCLE	LPPFED	LIG_APCC_ABBA_1	0.3056
p.E52Q	SW756	cervix	COSMIC	LPPFED	LIG_APCC_ABBA_1	0.3056
p.P42L	SIDM00878	Breast Carcinoma	GDSC	LPPFED	LIG_APCC_ABBA_1	0.2222
p.P42L	ACH-000930	Breast Cancer	CCLE	LPPFED	LIG_APCC_ABBA_1	0.2222
p.P42L	HCC1569	breast	COSMIC	LPPFED	LIG_APCC_ABBA_1	0.2222
p.G61E	SIDM00225	Melanoma	GDSC	LPPFED	LIG_APCC_ABBA_1	0.0556
p.G61E	ACH-002143	Skin Cancer	CCLE	LPPFED	LIG_APCC_ABBA_1	0.0556
p.G61E	IST-MEL1	skin	COSMIC	LPPFED	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49736	DNA replication licensing factor MCM2	LIG_APCC_ABBA_1	46:51	LPPFED	APC,CDC20,FZR1	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons