DegronMD

Uniprot ID: P49736

Source protein: DNA replication licensing factor MCM2

Source gene: MCM2

Class: DEG_SPOP_SBC_1

Location: 23:27

E3 ligase: SPOP

DEGRON score: 0.9038

ASA_SCORE: 87.3

COIL: 0.9556

CONS_SCORE: 0.1583

DSS_SCORE: 0.8214

HELIX: 0.019

FCONS_SCORE: 0.9067

RIG_SCORE: 0.5435

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R18W	TCGA-06-5416	GBM	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18W	DO10880	GBM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.D22G	TCGA-AX-A1CE	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.3056
p.D22G	DO42280	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.3056
p.D36N	TCGA-UY-A9PH	BLCA	TCGA	PLTSS	DEG_SPOP_SBC_1	0.0833
p.D36N	DO223594	BLCA	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.R18P	DO229346	LAML	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM00353	Other Sarcomas	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM00411	Pancreatic Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM00535	Chondrosarcoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM00619	Thyroid Gland Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM00596	Endometrial Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM00997	Thyroid Gland Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM01511	Gastric Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM01336	Glioblastoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM01446	Glioblastoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R18P	SIDM01443	Gastric Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1944
p.R33Q	DO228947	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R33Q	SIDM00425	Ovarian Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R33Q	SIDM01194	Hepatocellular Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R33Q	SIDM00350	Head and Neck Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R33Q	SIDM01093	Cervical Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R33Q	SIDM00358	Gastric Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R33Q	SIDM00359	Colorectal Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.D22Y	SIDM00367	Small Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.3056
p.D22Y	ACH-002197	Lung Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	0.3056
p.D22Y	SBC-3	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.3056
p.T25A	SIDM01045	Endometrial Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.825
p.T25A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	0.825
p.T25A	EN	endometrium	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	294:298	PLTSS	SPOP	0.9863	More...
O60284	Suppression of tumorigenicity 18 protein	DEG_SPOP_SBC_1	629:633	PLTSS	SPOP	0.9793	More...
O75563	Src kinase-associated phosphoprotein 2	DEG_SPOP_SBC_1	249:253	PLTSS	SPOP	0.9972	More...
O95486	Protein transport protein Sec24A	DEG_SPOP_SBC_1	226:230	PLTSS	SPOP	0.9934	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	1024:1028	PLTSS	SPOP	0.8767	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	23:27	PLTSS	SPOP	0.9038	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1038:1042	PLTSS	SPOP	0.6344	More...
Q15475	Homeobox protein SIX1	DEG_SPOP_SBC_1	274:278	PLTSS	SPOP	0.5507	More...
Q15691	Microtubule-associated protein RP/EB family member 1	DEG_SPOP_SBC_1	152:156	PLTSS	SPOP	0.9872	More...
Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	DEG_SPOP_SBC_1	157:161	PLTSS	SPOP	0.9878	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	774:778	PLTSS	SPOP	0.9452	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	355:359	PLTSS	SPOP	0.9297	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	254:258	PLTSS	SPOP	0.949	More...
Q7Z434	Mitochondrial antiviral-signaling protein	DEG_SPOP_SBC_1	189:193	PLTSS	SPOP	0.9989	More...
Q8NEP3	Dynein axonemal assembly factor 1	DEG_SPOP_SBC_1	671:675	PLTSS	SPOP	0.9436	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SPOP_SBC_1	775:779	PLTSS	SPOP	0.8711	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1750:1754	PLTSS	SPOP	0.9632	More...
Q96RU2	Ubiquitin carboxyl-terminal hydrolase 28	DEG_SPOP_SBC_1	514:518	PLTSS	SPOP	0.9579	More...
Q96RW7	Hemicentin-1	DEG_SPOP_SBC_1	2817:2821	PLTSS	SPOP	0.5877	More...
Q99633	Pre-mRNA-splicing factor 18	DEG_SPOP_SBC_1	58:62	PLTSS	SPOP	0.9188	More...
Q9BZE9	Tether containing UBX domain for GLUT4	DEG_SPOP_SBC_1	261:265	PLTSS	SPOP	0.9718	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	468:472	PLTSS	SPOP	0.7927	More...
Q9NPI1	Bromodomain-containing protein 7	DEG_SPOP_SBC_1	120:124	PLTSS	SPOP	0.9763	More...
Q9UDV6	Zinc finger protein 212	DEG_SPOP_SBC_1	17:21	PLTSS	SPOP	0.99	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	49:53	PLTSS	SPOP	0.9611	More...
Q6ZMY3	SPOC domain-containing protein 1	DEG_SPOP_SBC_1	193:197	PLTSS	SPOP	0.8764	More...
Q8IWR0	Zinc finger CCCH domain-containing protein 7A	DEG_SPOP_SBC_1	347:351	PLTSS	SPOP	0.9188	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	568:572	PLTSS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTSS

Degron related mutations and impact score

Drug responses associated with MCM2 mutations

All proteins holding degron of PLTSS