DegronMD - O43586(PSTPIP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E339K	TCGA-66-2727	LUSC	TCGA	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation altering degron motif	0.7022
p.E339K	TCGA-F4-6570	COAD	TCGA	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation altering degron motif	0.7022
p.V344I	TCGA-A5-A0G1	UCEC	TCGA	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.1944
p.V292A	TCGA-AA-3947	COAD	TCGA	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation altering degron motif	0.6936
p.V292A	DO8192	COAD	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation altering degron motif	0.6936
p.A349T	TCGA-AP-A1DV	UCEC	TCGA	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.0556
p.D289N	TCGA-AX-A2HD	UCEC	TCGA	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.25
p.D289N	TCGA-AX-A2HD	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.D289N	DO42608	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.25
p.D289N	DO42608	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.D289N	SIDM00291	Melanoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.25
p.D289N	SIDM00291	Melanoma	GDSC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.D289N	ACH-001608	Brain Cancer	CCLE	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.25
p.D289N	ACH-001608	Brain Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.D289N	ACH-002040	Skin Cancer	CCLE	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.25
p.D289N	ACH-002040	Skin Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.S323L	TCGA-B5-A3FA	UCEC	TCGA	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation altering degron motif	0.7667
p.S323L	DO52402	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation altering degron motif	0.7667
p.T335A	TCGA-D1-A103	UCEC	TCGA	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation altering degron motif	0.7139
p.P336R	TCGA-D8-A143	BRCA	TCGA	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation altering degron motif	0.7512
p.V282M	TCGA-IB-7651	PAAD	TCGA	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.0556
p.V282M	DO46657	PAAD	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.0556
p.R340Q	TCGA-WS-AB45	COAD	TCGA	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.3056
p.G336E	DO51918	BLCA	ICGC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation altering degron motif	0.7199
p.G298R	DO225114	BRCA	ICGC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7568
p.P316R	DO1319	BRCA	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.25
p.R321Q	DO51734	COAD	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation altering degron motif	0.7329
p.R321Q	DO222769	COCA	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation altering degron motif	0.7329
p.R321Q	DO230592	PRAD	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation altering degron motif	0.7329
p.E320K	DO10443	COAD	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation altering degron motif	0.7022
p.E320K	DO26478	LUSC	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation altering degron motif	0.7022
p.S290C	DO229346	LAML	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.2778
p.S290C	DO229346	LAML	ICGC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.2222
p.V325F	DO229008	LICA	ICGC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.0833
p.V325F	DO229008	LICA	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.P318H	DO230530	LUSC	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation blocking phosphorylation signal	0.75
p.A284E	DO26716	LUSC	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1111
p.A284E	DO26716	LUSC	ICGC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.0556
p.R282L	DO37571	SKCM	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.0556
p.I333R	DO47646	SKCM	ICGC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation blocking phosphorylation signal	0.75
p.I333R	DO47646	SKCM	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation blocking phosphorylation signal	0.5
p.S297R	DO229216	THCA	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation altering degron motif	0.7427
p.S297R	DO229216	THCA	ICGC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation altering degron motif	0.7427
p.P341L	DO229242	THCA	ICGC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.2778
p.A287T	DO42033	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1944
p.A287T	DO42033	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.A287T	DO52402	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1944
p.A287T	DO52402	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1389
p.V282A	DO42023	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.0556
p.T315A	DO42312	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2222
p.A330T	DO43186	UCEC	ICGC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.2222
p.A330T	DO43186	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1389
p.R346W	DO41584	UCEC	ICGC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.1389
p.V325I	DO42472	UCEC	ICGC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.0833
p.V325I	DO42472	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.D289Y	SIDM01117	Small Cell Lung Carcinoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.25
p.D289Y	SIDM01117	Small Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.D289Y	ACH-002176	Lung Cancer	CCLE	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.25
p.D289Y	ACH-002176	Lung Cancer	CCLE	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.G306S	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.0833
p.G306S	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1111
p.G306S	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.0833
p.G306S	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1111
p.P303L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1667
p.P303L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.P303L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.1667
p.P303L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1944
p.Y345C	SIDM00581	Glioblastoma	GDSC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.1667
p.Y345C	ACH-000738	Brain Cancer	CCLE	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.1667
p.Y345C	GB-1	central nervous system	COSMIC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.1667
p.A325E	SIDM00690	Head and Neck Carcinoma	GDSC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.0833
p.A325E	SIDM00690	Head and Neck Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.A325E	ACH-002251	Head and Neck Cancer	CCLE	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.0833
p.A325E	ACH-002251	Head and Neck Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.A325E	JHU-029	upper aerodigestive tract	COSMIC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.0833
p.A325E	JHU-029	upper aerodigestive tract	COSMIC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.2778
p.S330F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.2222
p.S330F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1389
p.S330F	ACH-002215	Lymphoma	CCLE	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.2222
p.S330F	ACH-002215	Lymphoma	CCLE	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.1389
p.E339D	SIDM00140	Melanoma	GDSC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation altering degron motif	0.6758
p.E339D	ACH-000968	Skin Cancer	CCLE	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation altering degron motif	0.6758
p.G343D	ACH-002508	Skin Cancer	CCLE	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.2222
p.Y326C	GB-1	central nervous system	COSMIC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.1111
p.Y326C	GB-1	central nervous system	COSMIC	PKTTS	DEG_SPOP_SBC_1	319:323	Mutation rewiring degron network	0.25
p.A306E	JHU-029	upper aerodigestive tract	COSMIC	VTPLTS	DEG_SCF_FBW7_1	292:297	Mutation rewiring degron network	0.0833
p.A306E	JHU-029	upper aerodigestive tract	COSMIC	PLTSS	DEG_SPOP_SBC_1	294:298	Mutation rewiring degron network	0.1111
p.Y342C	GB-1	central nervous system	COSMIC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation rewiring degron network	0.25
p.A339T	SNU-175	large intestine	COSMIC	LTPTPE	DEG_SCF_FBW7_2	334:339	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSTPIP1

UniProt ID: O43586

Entrez ID: 9051

Protein name: Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSTPIP1 in