DegronMD

Uniprot ID: O43586

Source protein: Proline-serine-threonine phosphatase-interacting protein 1

Source gene: PSTPIP1

Class: DEG_SCF_FBW7_2

Location: 334:339

E3 ligase: FBXW7

DEGRON score: 0.7523

ASA_SCORE: 82.35

COIL: 0.8835

CONS_SCORE: 0.487

DSS_SCORE: 0.553

HELIX: 0.0762

FCONS_SCORE: 0.995

RIG_SCORE: 0.7059

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E339K	TCGA-66-2727	LUSC	TCGA	LTPTPE	DEG_SCF_FBW7_2	0.7022
p.E339K	TCGA-F4-6570	COAD	TCGA	LTPTPE	DEG_SCF_FBW7_2	0.7022
p.V344I	TCGA-A5-A0G1	UCEC	TCGA	LTPTPE	DEG_SCF_FBW7_2	0.1944
p.A349T	TCGA-AP-A1DV	UCEC	TCGA	LTPTPE	DEG_SCF_FBW7_2	0.0556
p.T335A	TCGA-D1-A103	UCEC	TCGA	LTPTPE	DEG_SCF_FBW7_2	0.7139
p.P336R	TCGA-D8-A143	BRCA	TCGA	LTPTPE	DEG_SCF_FBW7_2	0.7512
p.R340Q	TCGA-WS-AB45	COAD	TCGA	LTPTPE	DEG_SCF_FBW7_2	0.3056
p.G336E	DO51918	BLCA	ICGC	LTPTPE	DEG_SCF_FBW7_2	0.7199
p.V325F	DO229008	LICA	ICGC	LTPTPE	DEG_SCF_FBW7_2	0.0833
p.I333R	DO47646	SKCM	ICGC	LTPTPE	DEG_SCF_FBW7_2	0.75
p.P341L	DO229242	THCA	ICGC	LTPTPE	DEG_SCF_FBW7_2	0.2778
p.A330T	DO43186	UCEC	ICGC	LTPTPE	DEG_SCF_FBW7_2	0.2222
p.R346W	DO41584	UCEC	ICGC	LTPTPE	DEG_SCF_FBW7_2	0.1389
p.V325I	DO42472	UCEC	ICGC	LTPTPE	DEG_SCF_FBW7_2	0.0833
p.Y345C	SIDM00581	Glioblastoma	GDSC	LTPTPE	DEG_SCF_FBW7_2	0.1667
p.Y345C	ACH-000738	Brain Cancer	CCLE	LTPTPE	DEG_SCF_FBW7_2	0.1667
p.Y345C	GB-1	central_nervous_system	COSMIC	LTPTPE	DEG_SCF_FBW7_2	0.1667
p.A325E	SIDM00690	Head and Neck Carcinoma	GDSC	LTPTPE	DEG_SCF_FBW7_2	0.0833
p.A325E	ACH-002251	Head and Neck Cancer	CCLE	LTPTPE	DEG_SCF_FBW7_2	0.0833
p.A325E	JHU-029	upper_aerodigestive_tract	COSMIC	LTPTPE	DEG_SCF_FBW7_2	0.0833
p.S330F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPTPE	DEG_SCF_FBW7_2	0.2222
p.S330F	ACH-002215	Lymphoma	CCLE	LTPTPE	DEG_SCF_FBW7_2	0.2222
p.E339D	SIDM00140	Melanoma	GDSC	LTPTPE	DEG_SCF_FBW7_2	0.6758
p.E339D	ACH-000968	Skin Cancer	CCLE	LTPTPE	DEG_SCF_FBW7_2	0.6758
p.G343D	ACH-002508	Skin Cancer	CCLE	LTPTPE	DEG_SCF_FBW7_2	0.2222
p.Y326C	GB-1	central_nervous_system	COSMIC	LTPTPE	DEG_SCF_FBW7_2	0.1111
p.Y342C	GB-1	central_nervous_system	COSMIC	LTPTPE	DEG_SCF_FBW7_2	0.25
p.A339T	SNU-175	large_intestine	COSMIC	LTPTPE	DEG_SCF_FBW7_2	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPTPE

Degron related mutations and impact score

Drug responses associated with PSTPIP1 mutations

All proteins holding degron of LTPTPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SCF_FBW7_2	334:339	LTPTPE	FBXW7	0.7523	More...