DegronMD

Uniprot ID: O43586

Source protein: Proline-serine-threonine phosphatase-interacting protein 1

Source gene: PSTPIP1

Class: DEG_SCF_FBW7_1

Location: 292:297

E3 ligase: FBXW7

DEGRON score: 0.9911

ASA_SCORE: 58.6167

COIL: 0.824

CONS_SCORE: 0.4833

DSS_SCORE: 0.4835

HELIX: 0.0663

FCONS_SCORE: 0.9519

RIG_SCORE: 0.7393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V292A	TCGA-AA-3947	COAD	TCGA	VTPLTS	DEG_SCF_FBW7_1	0.6936
p.V292A	DO8192	COAD	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.6936
p.D289N	TCGA-AX-A2HD	UCEC	TCGA	VTPLTS	DEG_SCF_FBW7_1	0.25
p.D289N	DO42608	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.25
p.D289N	SIDM00291	Melanoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	0.25
p.D289N	ACH-001608	Brain Cancer	CCLE	VTPLTS	DEG_SCF_FBW7_1	0.25
p.D289N	ACH-002040	Skin Cancer	CCLE	VTPLTS	DEG_SCF_FBW7_1	0.25
p.V282M	TCGA-IB-7651	PAAD	TCGA	VTPLTS	DEG_SCF_FBW7_1	0.0556
p.V282M	DO46657	PAAD	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.0556
p.S290C	DO229346	LAML	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.2778
p.A284E	DO26716	LUSC	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.1111
p.R282L	DO37571	SKCM	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.0556
p.S297R	DO229216	THCA	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.7427
p.A287T	DO42033	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.1944
p.A287T	DO52402	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.1944
p.V282A	DO42023	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.0556
p.D289Y	SIDM01117	Small Cell Lung Carcinoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	0.25
p.D289Y	ACH-002176	Lung Cancer	CCLE	VTPLTS	DEG_SCF_FBW7_1	0.25
p.G306S	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	0.0833
p.G306S	JEKO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPLTS	DEG_SCF_FBW7_1	0.0833
p.P303L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VTPLTS	DEG_SCF_FBW7_1	0.1667
p.P303L	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	0.1667
p.A306E	JHU-029	upper_aerodigestive_tract	COSMIC	VTPLTS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SCF_FBW7_1	292:297	VTPLTS	FBXW7	0.9911	More...
P19827	Inter-alpha-trypsin inhibitor heavy chain H1	DEG_SCF_FBW7_1	603:608	VTPLTS	FBXW7	0.6687	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons