DegronMD

Uniprot ID: P19827

Source protein: Inter-alpha-trypsin inhibitor heavy chain H1

Source gene: ITIH1

Class: DEG_SCF_FBW7_1

Location: 603:608

E3 ligase: FBXW7

DEGRON score: 0.6687

ASA_SCORE: 35.1833

COIL: 0.6967

CONS_SCORE: 0.6019

DSS_SCORE: 0.2971

HELIX: 0.1887

FCONS_SCORE: 1.3428

RIG_SCORE: 0.782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S597L	TCGA-85-8277	LUSC	TCGA	VTPLTS	DEG_SCF_FBW7_1	0.1667
p.S597L	TCGA-AG-A02N	READ	TCGA	VTPLTS	DEG_SCF_FBW7_1	0.1667
p.Q617H	TCGA-D3-A2JC	SKCM	TCGA	VTPLTS	DEG_SCF_FBW7_1	0.0833
p.G601W	TCGA-D3-A3CE	SKCM	TCGA	VTPLTS	DEG_SCF_FBW7_1	0.2778
p.G613S	TCGA-EE-A3JD	SKCM	TCGA	VTPLTS	DEG_SCF_FBW7_1	0.1944
p.G613V	TCGA-OR-A5LJ	ACC	TCGA	VTPLTS	DEG_SCF_FBW7_1	0.1944
p.A594T	DO23120	LINC	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.0833
p.A594T	DO228138	PBCA	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.0833
p.P606L	DO220239	SARC	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.7582
p.P613H	DO37619	SKCM	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.1944
p.D599N	DO37782	SKCM	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.2222
p.T610M	DO222387	STAD	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.2778
p.N595S	DO38192	STAD	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.1111
p.P606S	DO41235	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	0.6752
p.P605R	SIDM01144	Gastric Carcinoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	0.7512
p.P605R	NCI-SNU-5	stomach	COSMIC	VTPLTS	DEG_SCF_FBW7_1	0.7512
p.N605K	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VTPLTS	DEG_SCF_FBW7_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SCF_FBW7_1	292:297	VTPLTS	FBXW7	0.9911	More...
P19827	Inter-alpha-trypsin inhibitor heavy chain H1	DEG_SCF_FBW7_1	603:608	VTPLTS	FBXW7	0.6687	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons