DegronMD - P19827(ITIH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S597L	TCGA-85-8277	LUSC	TCGA	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.1667
p.S597L	TCGA-AG-A02N	READ	TCGA	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.1667
p.Q617H	TCGA-D3-A2JC	SKCM	TCGA	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.0833
p.G601W	TCGA-D3-A3CE	SKCM	TCGA	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.2778
p.G613S	TCGA-EE-A3JD	SKCM	TCGA	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.1944
p.G613V	TCGA-OR-A5LJ	ACC	TCGA	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.1944
p.A594T	DO23120	LINC	ICGC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.0833
p.A594T	DO228138	PBCA	ICGC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.0833
p.P606L	DO220239	SARC	ICGC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation altering degron motif	0.7582
p.P613H	DO37619	SKCM	ICGC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.1944
p.D599N	DO37782	SKCM	ICGC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.2222
p.T610M	DO222387	STAD	ICGC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.2778
p.N595S	DO38192	STAD	ICGC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation rewiring degron network	0.1111
p.P606S	DO41235	UCEC	ICGC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation altering degron motif	0.6752
p.P605R	SIDM01144	Gastric Carcinoma	GDSC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation altering degron motif	0.7512
p.P605R	NCI-SNU-5	stomach	COSMIC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation altering degron motif	0.7512
p.N605K	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VTPLTS	DEG_SCF_FBW7_1	603:608	Mutation altering degron motif	0.6918

Kaplan plot for ITIH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITIH1

UniProt ID: P19827

Entrez ID: 3697

Protein name: Inter-alpha-trypsin inhibitor heavy chain H1 (ITI heavy chain H1) (ITI-HC1) (Inter-alpha-inhibitor heavy chain 1) (Inter-alpha-trypsin inhibitor complex component III) (Serum-derived hyaluronan-associated protein) (SHAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITIH1 in