DegronMD

Uniprot ID: O43586

Source protein: Proline-serine-threonine phosphatase-interacting protein 1

Source gene: PSTPIP1

Class: DEG_SPOP_SBC_1

Location: 319:323

E3 ligase: SPOP

DEGRON score: 0.9895

ASA_SCORE: 82.54

COIL: 0.8196

CONS_SCORE: 0.5075

DSS_SCORE: 0.4623

HELIX: 0.1256

FCONS_SCORE: 1.0169

RIG_SCORE: 0.6788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S323L	TCGA-B5-A3FA	UCEC	TCGA	PKTTS	DEG_SPOP_SBC_1	0.7667
p.S323L	DO52402	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.7667
p.P316R	DO1319	BRCA	ICGC	PKTTS	DEG_SPOP_SBC_1	0.25
p.R321Q	DO51734	COAD	ICGC	PKTTS	DEG_SPOP_SBC_1	0.7329
p.R321Q	DO222769	COCA	ICGC	PKTTS	DEG_SPOP_SBC_1	0.7329
p.R321Q	DO230592	PRAD	ICGC	PKTTS	DEG_SPOP_SBC_1	0.7329
p.E320K	DO10443	COAD	ICGC	PKTTS	DEG_SPOP_SBC_1	0.7022
p.E320K	DO26478	LUSC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.7022
p.V325F	DO229008	LICA	ICGC	PKTTS	DEG_SPOP_SBC_1	0.2778
p.P318H	DO230530	LUSC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.75
p.I333R	DO47646	SKCM	ICGC	PKTTS	DEG_SPOP_SBC_1	0.5
p.T315A	DO42312	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.2222
p.A330T	DO43186	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.1389
p.V325I	DO42472	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.2778
p.A325E	SIDM00690	Head and Neck Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.2778
p.A325E	ACH-002251	Head and Neck Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	0.2778
p.A325E	JHU-029	upper_aerodigestive_tract	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.2778
p.S330F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.1389
p.S330F	ACH-002215	Lymphoma	CCLE	PKTTS	DEG_SPOP_SBC_1	0.1389
p.Y326C	GB-1	central_nervous_system	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	319:323	PKTTS	SPOP	0.9895	More...
O75534	Cold shock domain-containing protein E1	DEG_SPOP_SBC_1	441:445	PKTTS	SPOP	0.8677	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	241:245	PKTTS	SPOP	0.9335	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	323:327	PKTTS	SPOP	0.8843	More...
Q8N131	Porimin	DEG_SPOP_SBC_1	116:120	PKTTS	SPOP	0.9855	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	904:908	PKTTS	SPOP	0.9776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons