DegronMD

Uniprot ID: O75534

Source protein: Cold shock domain-containing protein E1

Source gene: CSDE1

Class: DEG_SPOP_SBC_1

Location: 441:445

E3 ligase: SPOP

DEGRON score: 0.8677

ASA_SCORE: 89.76

COIL: 0.9368

CONS_SCORE: 0.3643

DSS_SCORE: 0.6269

HELIX: 0.0258

FCONS_SCORE: 0.7233

RIG_SCORE: 0.6646

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R450I	TCGA-05-5423	LUAD	TCGA	PKTTS	DEG_SPOP_SBC_1	0.3056
p.R450I	TCGA-AA-A010	COAD	TCGA	PKTTS	DEG_SPOP_SBC_1	0.3056
p.R450I	SIDM00118	Colorectal Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.3056
p.R450I	HCC2998	large_intestine	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.3056
p.P443S	TCGA-EE-A20C	SKCM	TCGA	PKTTS	DEG_SPOP_SBC_1	0.6752
p.G448R	DO233715	GACA	ICGC	PKTTS	DEG_SPOP_SBC_1	0.3611
p.D431G	DO12520	GBM	ICGC	PKTTS	DEG_SPOP_SBC_1	0.5
p.T452N	DO14478	HNSC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.5833
p.I454M	DO26870	LUSC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.0833
p.G434W	DO27652	LUSC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.5833
p.N455S	DO222670	MELA	ICGC	PKTTS	DEG_SPOP_SBC_1	0.0556
p.N455S	DO38057	SKCM	ICGC	PKTTS	DEG_SPOP_SBC_1	0.0556
p.T446M	DO47827	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	0.3056
p.R442H	DO47757	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	0.8244
p.T438A	DO223286	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.25
p.H436N	DO43971	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.1944
p.I433M	SIDM00544	Neuroblastoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.1111
p.I433M	SIDM00315	Glioblastoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.1111
p.I433M	SIDM00358	Gastric Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.1111
p.I433M	SIDM00554	Ovarian Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.1111
p.I433M	SIDM00166	Other Solid Cancers	GDSC	PKTTS	DEG_SPOP_SBC_1	0.1111
p.I433M	YKG-1	central_nervous_system	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.1111
p.I433M	RERF-GC-1B	stomach	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.1111
p.I433M	KURAMOCHI	ovary	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.1111
p.I433M	GOTO	autonomic_ganglia	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.1111
p.R450K	SIDM00534	Colorectal Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.3056
p.R450K	HT-115	large_intestine	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.3056
p.P446A	CGTH-W-1	thyroid	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	319:323	PKTTS	SPOP	0.9895	More...
O75534	Cold shock domain-containing protein E1	DEG_SPOP_SBC_1	441:445	PKTTS	SPOP	0.8677	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	241:245	PKTTS	SPOP	0.9335	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	323:327	PKTTS	SPOP	0.8843	More...
Q8N131	Porimin	DEG_SPOP_SBC_1	116:120	PKTTS	SPOP	0.9855	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	904:908	PKTTS	SPOP	0.9776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKTTS

Degron related mutations and impact score

Drug responses associated with CSDE1 mutations

All proteins holding degron of PKTTS