DegronMD

Uniprot ID: Q86UU1

Source protein: Pleckstrin homology-like domain family B member 1

Source gene: PHLDB1

Class: DEG_SPOP_SBC_1

Location: 904:908

E3 ligase: SPOP

DEGRON score: 0.9776

ASA_SCORE: 90.82

COIL: 0.7402

CONS_SCORE: 0.3273

DSS_SCORE: 0.4844

HELIX: 0.2442

FCONS_SCORE: 1.0387

RIG_SCORE: 0.7328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S908L	TCGA-AA-A00N	COAD	TCGA	PKTTS	DEG_SPOP_SBC_1	0.7667
p.S908L	DO9876	COAD	ICGC	PKTTS	DEG_SPOP_SBC_1	0.7667
p.R901K	TCGA-B9-A44B	KIRP	TCGA	PKTTS	DEG_SPOP_SBC_1	0.25
p.R901K	DO44496	KIRP	ICGC	PKTTS	DEG_SPOP_SBC_1	0.25
p.E912Q	DO50757	LICA	ICGC	PKTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	319:323	PKTTS	SPOP	0.9895	More...
O75534	Cold shock domain-containing protein E1	DEG_SPOP_SBC_1	441:445	PKTTS	SPOP	0.8677	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	241:245	PKTTS	SPOP	0.9335	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	323:327	PKTTS	SPOP	0.8843	More...
Q8N131	Porimin	DEG_SPOP_SBC_1	116:120	PKTTS	SPOP	0.9855	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	904:908	PKTTS	SPOP	0.9776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons