DegronMD

Uniprot ID: P53814

Source protein: Smoothelin

Source gene: SMTN

Class: DEG_SPOP_SBC_1

Location: 241:245

E3 ligase: SPOP

DEGRON score: 0.9335

ASA_SCORE: 103.86

COIL: 0.9478

CONS_SCORE: 0.3855

DSS_SCORE: 0.9068

HELIX: 0.0172

FCONS_SCORE: 0.9617

RIG_SCORE: 0.4836

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T242A	SIDM01412	Oral Cavity Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.7139
p.G232D	ACH-000690	Lung Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	0.0833
p.S245I	ACH-000901	Lung Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	0.8453
p.P240L	ACH-001550	Skin Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	0.3056
p.P240L	MCC13	skin	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.3056
p.P246L	ACH-002166	Skin Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	0.3056
p.P246L	MZ7-mel	skin	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.3056
p.S252N	NCI-H1048	lung	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	319:323	PKTTS	SPOP	0.9895	More...
O75534	Cold shock domain-containing protein E1	DEG_SPOP_SBC_1	441:445	PKTTS	SPOP	0.8677	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	241:245	PKTTS	SPOP	0.9335	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	323:327	PKTTS	SPOP	0.8843	More...
Q8N131	Porimin	DEG_SPOP_SBC_1	116:120	PKTTS	SPOP	0.9855	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	904:908	PKTTS	SPOP	0.9776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons