DegronMD - P53814(SMTN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S378Y	TCGA-18-3421	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	374:378	Mutation altering degron motif	0.712
p.S378Y	DO27652	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation altering degron motif	0.712
p.V673I	TCGA-19-1787	GBM	TCGA	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0833
p.V673I	TCGA-AA-A022	COAD	TCGA	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0833
p.V673I	DO10647	COAD	ICGC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0833
p.V673I	DO13522	GBM	ICGC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0833
p.V673I	DO50970	LICA	ICGC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0833
p.E633Q	TCGA-86-6562	LUAD	TCGA	LQEARGR	SCF_FBXL2	631:637	Mutation altering degron motif	0.5633
p.E633Q	DO24013	LUAD	ICGC	LQEARGR	SCF_FBXL2	631:637	Mutation altering degron motif	0.5633
p.L191M	TCGA-A5-A0G2	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2222
p.L191M	DO41235	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2222
p.R192Q	TCGA-AX-A0J0	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.25
p.R192Q	DO41133	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.25
p.V187G	TCGA-BC-A3KF	LIHC	TCGA	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1389
p.V187G	TCGA-BC-A3KF	LIHC	TCGA	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation rewiring degron network	0.0833
p.V187G	TCGA-BC-A3KF	LIHC	TCGA	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1111
p.V187G	DO22990	LIHC	ICGC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1389
p.V187G	DO22990	LIHC	ICGC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation rewiring degron network	0.0833
p.V187G	DO22990	LIHC	ICGC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1111
p.E169D	TCGA-CM-6674	COAD	TCGA	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.2222
p.E169D	TCGA-CM-6674	COAD	TCGA	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation rewiring degron network	0.2222
p.E169D	DO10092	COAD	ICGC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.2222
p.E169D	DO10092	COAD	ICGC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation rewiring degron network	0.2222
p.L191P	TCGA-CV-7235	HNSC	TCGA	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2222
p.L191P	DO15102	HNSC	ICGC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2222
p.R694C	TCGA-D1-A15X	UCEC	TCGA	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694C	DO43274	UCEC	ICGC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694C	ACH-000972	Endometrial/Uterine Cancer	CCLE	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.P386T	TCGA-D1-A1NZ	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1111
p.P386T	DO41536	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1111
p.P177T	TCGA-D3-A3CE	SKCM	TCGA	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.7031
p.P177T	TCGA-D3-A3CE	SKCM	TCGA	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.5919
p.P177T	DO37405	SKCM	ICGC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.7031
p.P177T	DO37405	SKCM	ICGC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.5919
p.R623Q	TCGA-D5-6920	COAD	TCGA	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.1111
p.R623Q	DO8127	COAD	ICGC	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.1111
p.R623Q	DO50442	ESAD	ICGC	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.1111
p.S379N	TCGA-HU-A4GT	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.3056
p.S379N	DO48020	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.3056
p.S379N	ACH-000965	Endometrial/Uterine Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.3056
p.S379N	RL95-2	endometrium	COSMIC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.3056
p.E696G	DO233160	GACA	ICGC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0556
p.Q632H	DO233709	GACA	ICGC	LQEARGR	SCF_FBXL2	631:637	Mutation altering degron motif	0.7582
p.R627W	DO233903	GACA	ICGC	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.2222
p.R680L	DO229015	LICA	ICGC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.2778
p.S379R	DO23258	LINC	ICGC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.3056
p.S201T	DO46673	PACA	ICGC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2778
p.R637W	DO229542	UTCA	ICGC	LQEARGR	SCF_FBXL2	631:637	Mutation altering degron motif	0.8634
p.R206G	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1389
p.R206G	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1389
p.P370T	SIDM00589	Oral Cavity Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2222
p.P370T	SIDM01511	Gastric Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2222
p.P370T	HSC-3	upper aerodigestive tract	COSMIC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2222
p.E178Q	SIDM00898	Breast Carcinoma	GDSC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.5633
p.E178Q	SIDM00898	Breast Carcinoma	GDSC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.6744
p.E178Q	AU565	breast	COSMIC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.5633
p.E178Q	AU565	breast	COSMIC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.6744
p.V384L	SIDM00943	Pancreatic Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1667
p.R694Q	SIDM00068	Colorectal Carcinoma	GDSC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R694Q	GEO	large intestine	COSMIC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.R173W	SIDM00217	Colorectal Carcinoma	GDSC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.8634
p.R173W	SIDM00217	Colorectal Carcinoma	GDSC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.8634
p.R173W	SNU-1040	large intestine	COSMIC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.8634
p.R173W	SNU-1040	large intestine	COSMIC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.8634
p.R171H	SIDM00125	Kidney Carcinoma	GDSC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.2778
p.R171H	SIDM00125	Kidney Carcinoma	GDSC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation rewiring degron network	0.2778
p.R171H	786-0	kidney	COSMIC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.2778
p.R171H	786-0	kidney	COSMIC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation rewiring degron network	0.2778
p.A203V	SIDM00316	Glioblastoma	GDSC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2222
p.A203V	SIDM00604	Oral Cavity Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.2222
p.G194C	SIDM01608	Endometrial Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.3056
p.T242A	SIDM01412	Oral Cavity Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.7139
p.E628Q	ACH-000074	Leukemia	CCLE	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.25
p.E628Q	ACH-000836	Head and Neck Cancer	CCLE	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.25
p.E628Q	ACH-000847	Gastric Cancer	CCLE	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.25
p.E628Q	KU812	haematopoietic and lymphoid tissue	COSMIC	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.25
p.G380D	ACH-000080	Leukemia	CCLE	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.2778
p.R637P	ACH-000607	Rhabdoid	CCLE	LQEARGR	SCF_FBXL2	631:637	Mutation altering degron motif	0.7512
p.R637P	KYM-1	soft tissue	COSMIC	LQEARGR	SCF_FBXL2	631:637	Mutation altering degron motif	0.7512
p.G232D	ACH-000690	Lung Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.0833
p.T188A	ACH-000762	Head and Neck Cancer	CCLE	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1111
p.T188A	ACH-000762	Head and Neck Cancer	CCLE	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation rewiring degron network	0.0556
p.T188A	ACH-000762	Head and Neck Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.1389
p.R384W	ACH-000804	Neuroblastoma	CCLE	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1667
p.G366D	ACH-000830	Lung Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1111
p.G366D	NCI-H1436	lung	COSMIC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1111
p.S245I	ACH-000901	Lung Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	241:245	Mutation altering degron motif	0.8453
p.V687M	ACH-000983	Leukemia	CCLE	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.3056
p.V687M	KCL-22	haematopoietic and lymphoid tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.3056
p.R683H	ACH-000999	Colon/Colorectal Cancer	CCLE	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.7133
p.R683H	SNU-1040	large intestine	COSMIC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.7133
p.G636R	ACH-001489	Lung Cancer	CCLE	LQEARGR	SCF_FBXL2	631:637	Mutation altering degron motif	0.7568
p.G636R	COR-L32	lung	COSMIC	LQEARGR	SCF_FBXL2	631:637	Mutation altering degron motif	0.7568
p.V184G	ACH-001523	Skin Cancer	CCLE	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.2222
p.V184G	ACH-001523	Skin Cancer	CCLE	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation rewiring degron network	0.1667
p.P240L	ACH-001550	Skin Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.3056
p.P240L	MCC13	skin	COSMIC	PKTTS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.3056
p.P246L	ACH-002166	Skin Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.3056
p.P246L	MZ7-mel	skin	COSMIC	PKTTS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.3056
p.E688Q	ACH-002235	Bladder Cancer	CCLE	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.2778
p.E688Q	DSH1	urinary tract	COSMIC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.2778
p.E684Q	KU812	haematopoietic and lymphoid tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.6744
p.H674P	TALL-1	haematopoietic and lymphoid tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.H674P	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1111
p.T174S	HuO-3N1	bone	COSMIC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6005
p.T174S	HuO-3N1	bone	COSMIC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.7116
p.R208Q	GEO	large intestine	COSMIC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.0833
p.E180Q	AU565	breast	COSMIC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6744
p.R174Q	KELLY	autonomic ganglia	COSMIC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.7329
p.R174Q	KELLY	autonomic ganglia	COSMIC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.7329
p.R631Q	KELLY	autonomic ganglia	COSMIC	LQEARGR	SCF_FBXL2	631:637	Mutation altering degron motif	0.7329
p.L639M	NCI-H1417	lung	COSMIC	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.2778
p.R642H	RCC10RGB	kidney	COSMIC	LQEARGR	SCF_FBXL2	631:637	Mutation rewiring degron network	0.1944
p.S252N	NCI-H1048	lung	COSMIC	PKTTS	DEG_SPOP_SBC_1	241:245	Mutation rewiring degron network	0.1389
p.R208G	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	195:199	Mutation rewiring degron network	0.0833
p.R175W	SNU-1040	large intestine	COSMIC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.8634
p.R175W	SNU-1040	large intestine	COSMIC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.8634
p.R173H	786-0	kidney	COSMIC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.8244
p.R173H	786-0	kidney	COSMIC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation altering degron motif	0.8244
p.A365D	CAL-72	bone	COSMIC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.0833
p.L182M	NCI-H1417	lung	COSMIC	PTPTPEGT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.2778
p.L182M	NCI-H1417	lung	COSMIC	PTPTPE	DEG_SCF_FBW7_2	173:178	Mutation rewiring degron network	0.2222
p.G692R	COR-L32	lung	COSMIC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1667
p.F383L	MLMA	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation rewiring degron network	0.1944
p.P372T	HSC-3	upper aerodigestive tract	COSMIC	PASSS	DEG_SPOP_SBC_1	374:378	Mutation blocking phosphorylation signal	0.7222
p.R693P	KYM-1	soft tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMTN

UniProt ID: P53814

Entrez ID: 6525

Protein name: Smoothelin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMTN in