DegronMD

Uniprot ID: P53814

Source protein: Smoothelin

Source gene: SMTN

Class: DEG_SPOP_SBC_1

Location: 682:686

E3 ligase: SPOP

DEGRON score: 0.9807

ASA_SCORE: 95.08

COIL: 0.7922

CONS_SCORE: 0.4874

DSS_SCORE: 0.5795

HELIX: 0.043

FCONS_SCORE: 1.0611

RIG_SCORE: 0.7546

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V673I	TCGA-19-1787	GBM	TCGA	ARTTT	DEG_SPOP_SBC_1	0.0833
p.V673I	TCGA-AA-A022	COAD	TCGA	ARTTT	DEG_SPOP_SBC_1	0.0833
p.V673I	DO10647	COAD	ICGC	ARTTT	DEG_SPOP_SBC_1	0.0833
p.V673I	DO13522	GBM	ICGC	ARTTT	DEG_SPOP_SBC_1	0.0833
p.V673I	DO50970	LICA	ICGC	ARTTT	DEG_SPOP_SBC_1	0.0833
p.R694C	TCGA-D1-A15X	UCEC	TCGA	ARTTT	DEG_SPOP_SBC_1	0.1111
p.R694C	DO43274	UCEC	ICGC	ARTTT	DEG_SPOP_SBC_1	0.1111
p.R694C	ACH-000972	Endometrial/Uterine Cancer	CCLE	ARTTT	DEG_SPOP_SBC_1	0.1111
p.E696G	DO233160	GACA	ICGC	ARTTT	DEG_SPOP_SBC_1	0.0556
p.R680L	DO229015	LICA	ICGC	ARTTT	DEG_SPOP_SBC_1	0.2778
p.R694Q	SIDM00068	Colorectal Carcinoma	GDSC	ARTTT	DEG_SPOP_SBC_1	0.1111
p.R694Q	GEO	large_intestine	COSMIC	ARTTT	DEG_SPOP_SBC_1	0.1111
p.V687M	ACH-000983	Leukemia	CCLE	ARTTT	DEG_SPOP_SBC_1	0.3056
p.V687M	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	0.3056
p.R683H	ACH-000999	Colon/Colorectal Cancer	CCLE	ARTTT	DEG_SPOP_SBC_1	0.7133
p.R683H	SNU-1040	large_intestine	COSMIC	ARTTT	DEG_SPOP_SBC_1	0.7133
p.E688Q	ACH-002235	Bladder Cancer	CCLE	ARTTT	DEG_SPOP_SBC_1	0.2778
p.E688Q	DSH1	urinary_tract	COSMIC	ARTTT	DEG_SPOP_SBC_1	0.2778
p.E684Q	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	0.6744
p.H674P	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	0.1111
p.H674P	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	0.1111
p.G692R	COR-L32	lung	COSMIC	ARTTT	DEG_SPOP_SBC_1	0.1667
p.R693P	KYM-1	soft_tissue	COSMIC	ARTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53814	Smoothelin	DEG_SPOP_SBC_1	682:686	ARTTT	SPOP	0.9807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons