DegronMD

Uniprot ID: P53814

Source protein: Smoothelin

Source gene: SMTN

Class: SCF_FBXL2

Location: 631:637

E3 ligase: FBXL2

DEGRON score: 0.6289

ASA_SCORE: 108.1571

COIL: 0.4509

CONS_SCORE: 0.4869

DSS_SCORE: 0.7335

HELIX: 0.5464

FCONS_SCORE: 1.0383

RIG_SCORE: 0.6145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E633Q	TCGA-86-6562	LUAD	TCGA	LQEARGR	SCF_FBXL2	0.5633
p.E633Q	DO24013	LUAD	ICGC	LQEARGR	SCF_FBXL2	0.5633
p.R623Q	TCGA-D5-6920	COAD	TCGA	LQEARGR	SCF_FBXL2	0.1111
p.R623Q	DO8127	COAD	ICGC	LQEARGR	SCF_FBXL2	0.1111
p.R623Q	DO50442	ESAD	ICGC	LQEARGR	SCF_FBXL2	0.1111
p.Q632H	DO233709	GACA	ICGC	LQEARGR	SCF_FBXL2	0.7582
p.R627W	DO233903	GACA	ICGC	LQEARGR	SCF_FBXL2	0.2222
p.R637W	DO229542	UTCA	ICGC	LQEARGR	SCF_FBXL2	0.8634
p.E628Q	ACH-000074	Leukemia	CCLE	LQEARGR	SCF_FBXL2	0.25
p.E628Q	ACH-000836	Head and Neck Cancer	CCLE	LQEARGR	SCF_FBXL2	0.25
p.E628Q	ACH-000847	Gastric Cancer	CCLE	LQEARGR	SCF_FBXL2	0.25
p.E628Q	KU812	haematopoietic_and_lymphoid_tissue	COSMIC	LQEARGR	SCF_FBXL2	0.25
p.R637P	ACH-000607	Rhabdoid	CCLE	LQEARGR	SCF_FBXL2	0.7512
p.R637P	KYM-1	soft_tissue	COSMIC	LQEARGR	SCF_FBXL2	0.7512
p.G636R	ACH-001489	Lung Cancer	CCLE	LQEARGR	SCF_FBXL2	0.7568
p.G636R	COR-L32	lung	COSMIC	LQEARGR	SCF_FBXL2	0.7568
p.R631Q	KELLY	autonomic_ganglia	COSMIC	LQEARGR	SCF_FBXL2	0.7329
p.L639M	NCI-H1417	lung	COSMIC	LQEARGR	SCF_FBXL2	0.2778
p.R642H	RCC10RGB	kidney	COSMIC	LQEARGR	SCF_FBXL2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53814	Smoothelin	SCF_FBXL2	631:637	LQEARGR	FBXL2	0.6289	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons