DegronMD

Uniprot ID: P53814

Source protein: Smoothelin

Source gene: SMTN

Class: DEG_SCF_FBW7_2

Location: 173:178

E3 ligase: FBXW7

DEGRON score: 0.9102

ASA_SCORE: 100.6167

COIL: 0.9667

CONS_SCORE: 0.4146

DSS_SCORE: 0.7908

HELIX: 0.01

FCONS_SCORE: 1.0109

RIG_SCORE: 0.5665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V187G	TCGA-BC-A3KF	LIHC	TCGA	PTPTPE	DEG_SCF_FBW7_2	0.0833
p.V187G	DO22990	LIHC	ICGC	PTPTPE	DEG_SCF_FBW7_2	0.0833
p.E169D	TCGA-CM-6674	COAD	TCGA	PTPTPE	DEG_SCF_FBW7_2	0.2222
p.E169D	DO10092	COAD	ICGC	PTPTPE	DEG_SCF_FBW7_2	0.2222
p.P177T	TCGA-D3-A3CE	SKCM	TCGA	PTPTPE	DEG_SCF_FBW7_2	0.5919
p.P177T	DO37405	SKCM	ICGC	PTPTPE	DEG_SCF_FBW7_2	0.5919
p.E178Q	SIDM00898	Breast Carcinoma	GDSC	PTPTPE	DEG_SCF_FBW7_2	0.6744
p.E178Q	AU565	breast	COSMIC	PTPTPE	DEG_SCF_FBW7_2	0.6744
p.R173W	SIDM00217	Colorectal Carcinoma	GDSC	PTPTPE	DEG_SCF_FBW7_2	0.8634
p.R173W	SNU-1040	large_intestine	COSMIC	PTPTPE	DEG_SCF_FBW7_2	0.8634
p.R171H	SIDM00125	Kidney Carcinoma	GDSC	PTPTPE	DEG_SCF_FBW7_2	0.2778
p.R171H	786-0	kidney	COSMIC	PTPTPE	DEG_SCF_FBW7_2	0.2778
p.T188A	ACH-000762	Head and Neck Cancer	CCLE	PTPTPE	DEG_SCF_FBW7_2	0.0556
p.V184G	ACH-001523	Skin Cancer	CCLE	PTPTPE	DEG_SCF_FBW7_2	0.1667
p.T174S	HuO-3N1	bone	COSMIC	PTPTPE	DEG_SCF_FBW7_2	0.7116
p.R174Q	KELLY	autonomic_ganglia	COSMIC	PTPTPE	DEG_SCF_FBW7_2	0.7329
p.R175W	SNU-1040	large_intestine	COSMIC	PTPTPE	DEG_SCF_FBW7_2	0.8634
p.R173H	786-0	kidney	COSMIC	PTPTPE	DEG_SCF_FBW7_2	0.8244
p.L182M	NCI-H1417	lung	COSMIC	PTPTPE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P53814	Smoothelin	DEG_SCF_FBW7_2	173:178	PTPTPE	FBXW7	0.9102	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons