DegronMD - Q8N131(TMEM123)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q127E	TCGA-49-4486	LUAD	TCGA	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation rewiring degron network	0.1111
p.Q127E	TCGA-49-4486	LUAD	TCGA	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.Q127E	TCGA-DK-A3WW	BLCA	TCGA	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation rewiring degron network	0.1111
p.Q127E	TCGA-DK-A3WW	BLCA	TCGA	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1389
p.P116S	TCGA-AX-A1CE	UCEC	TCGA	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation altering degron motif	0.6752
p.P116S	TCGA-AX-A1CE	UCEC	TCGA	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation altering degron motif	0.6752
p.S126F	TCGA-BB-8601	HNSC	TCGA	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation rewiring degron network	0.1389
p.S126F	TCGA-BB-8601	HNSC	TCGA	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.1667
p.D114Y	DO43154	UCEC	ICGC	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation altering degron motif	0.7325
p.A118V	DO41199	UCEC	ICGC	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation altering degron motif	0.6936
p.A118V	DO41199	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation altering degron motif	0.6936
p.M107V	SIDM00901	Endometrial Carcinoma	GDSC	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation rewiring degron network	0.1944
p.M107V	SIDM00901	Endometrial Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.0833
p.M107V	ACH-000940	Endometrial/Uterine Cancer	CCLE	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation rewiring degron network	0.1944
p.M107V	ACH-000940	Endometrial/Uterine Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.0833
p.M107V	AN3-CA	endometrium	COSMIC	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation rewiring degron network	0.1944
p.M107V	AN3-CA	endometrium	COSMIC	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.0833
p.V116I	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation altering degron motif	0.7076
p.V116I	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation altering degron motif	0.7076
p.R105G	NCI-H596	lung	COSMIC	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation rewiring degron network	0.1389
p.G107D	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LKSTPKTT	DEG_SCF_FBW7_1	112:119	Mutation rewiring degron network	0.1944
p.G107D	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PKTTS	DEG_SPOP_SBC_1	116:120	Mutation rewiring degron network	0.0833

Kaplan plot for TMEM123 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM123

UniProt ID: Q8N131

Entrez ID: 114908

Protein name: Porimin (Keratinocytes-associated transmembrane protein 3) (KCT-3) (Pro-oncosis receptor inducing membrane injury) (Transmembrane protein 123)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM123 in