DegronMD

Uniprot ID: Q8N131

Source protein: Porimin

Source gene: TMEM123

Class: DEG_SPOP_SBC_1

Location: 116:120

E3 ligase: SPOP

DEGRON score: 0.9855

ASA_SCORE: 104.86

COIL: 0.9302

CONS_SCORE: 0.4521

DSS_SCORE: 0.5601

HELIX: 0.0196

FCONS_SCORE: 1.1388

RIG_SCORE: 0.7025

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q127E	TCGA-49-4486	LUAD	TCGA	PKTTS	DEG_SPOP_SBC_1	0.1389
p.Q127E	TCGA-DK-A3WW	BLCA	TCGA	PKTTS	DEG_SPOP_SBC_1	0.1389
p.P116S	TCGA-AX-A1CE	UCEC	TCGA	PKTTS	DEG_SPOP_SBC_1	0.6752
p.S126F	TCGA-BB-8601	HNSC	TCGA	PKTTS	DEG_SPOP_SBC_1	0.1667
p.A118V	DO41199	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.6936
p.M107V	SIDM00901	Endometrial Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.0833
p.M107V	ACH-000940	Endometrial/Uterine Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	0.0833
p.M107V	AN3-CA	endometrium	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.0833
p.V116I	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.7076
p.G107D	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	319:323	PKTTS	SPOP	0.9895	More...
O75534	Cold shock domain-containing protein E1	DEG_SPOP_SBC_1	441:445	PKTTS	SPOP	0.8677	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	241:245	PKTTS	SPOP	0.9335	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	323:327	PKTTS	SPOP	0.8843	More...
Q8N131	Porimin	DEG_SPOP_SBC_1	116:120	PKTTS	SPOP	0.9855	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	904:908	PKTTS	SPOP	0.9776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons