DegronMD

Uniprot ID: Q13029

Source protein: PR domain zinc finger protein 2

Source gene: PRDM2

Class: DEG_SPOP_SBC_1

Location: 323:327

E3 ligase: SPOP

DEGRON score: 0.8843

ASA_SCORE: 85.26

COIL: 0.8444

CONS_SCORE: 0.379

DSS_SCORE: 0.729

HELIX: 0.0982

FCONS_SCORE: 1.2388

RIG_SCORE: 0.661

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E332Q	TCGA-D8-A1JA	BRCA	TCGA	PKTTS	DEG_SPOP_SBC_1	0.1944
p.E332Q	DO2819	BRCA	ICGC	PKTTS	DEG_SPOP_SBC_1	0.1944
p.E336V	TCGA-IN-AB1X	STAD	TCGA	PKTTS	DEG_SPOP_SBC_1	0.0833
p.E314K	TCGA-PE-A5DD	BRCA	TCGA	PKTTS	DEG_SPOP_SBC_1	0.0833
p.E314K	DO219642	BRCA	ICGC	PKTTS	DEG_SPOP_SBC_1	0.0833
p.E322Q	DO2401	BRCA	ICGC	PKTTS	DEG_SPOP_SBC_1	0.3056
p.E321Q	DO38475	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	0.2778
p.A330V	DO38404	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	0.25
p.T333A	DO47867	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	0.1667
p.R315W	DO41584	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	0.2222
p.T325I	SIDM00562	Breast Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.7078
p.T325I	ACH-002163	Breast Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	0.7078
p.T325I	MRK-nu-1	breast	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.7078
p.L319V	SIDM01611	Endometrial Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	0.2222
p.L319V	ACH-000996	Endometrial/Uterine Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	0.2222
p.L320F	COLO-679	skin	COSMIC	PKTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	319:323	PKTTS	SPOP	0.9895	More...
O75534	Cold shock domain-containing protein E1	DEG_SPOP_SBC_1	441:445	PKTTS	SPOP	0.8677	More...
P53814	Smoothelin	DEG_SPOP_SBC_1	241:245	PKTTS	SPOP	0.9335	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	323:327	PKTTS	SPOP	0.8843	More...
Q8N131	Porimin	DEG_SPOP_SBC_1	116:120	PKTTS	SPOP	0.9855	More...
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	904:908	PKTTS	SPOP	0.9776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons