DegronMD - Q13029(PRDM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1560P	TCGA-23-1116	OV	TCGA	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1111
p.A1560P	DO30050	OV	ICGC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1111
p.D943Y	TCGA-97-7554	LUAD	TCGA	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation rewiring degron network	0.1111
p.D943Y	DO23592	LUAD	ICGC	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation rewiring degron network	0.1111
p.S720Y	TCGA-A5-A0G2	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.5833
p.V993I	TCGA-BR-8284	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.2222
p.V993I	TCGA-E6-A1LX	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.2222
p.V993I	DO38491	STAD	ICGC	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.2222
p.V993I	DO41020	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.2222
p.V993I	SIDM01752	Pancreatic Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.2222
p.S999Y	TCGA-C4-A0F7	BLCA	TCGA	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation altering degron motif	0.712
p.S1562L	TCGA-CV-7099	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1667
p.S1562L	SIDM00776	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1667
p.S1562L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1667
p.S1572C	TCGA-CV-7099	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation altering degron motif	0.7541
p.S1572C	DO15294	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation altering degron motif	0.7541
p.P1568S	TCGA-D1-A103	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation altering degron motif	0.6752
p.E332Q	TCGA-D8-A1JA	BRCA	TCGA	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1944
p.E332Q	DO2819	BRCA	ICGC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1944
p.R1580K	TCGA-D8-A1XQ	BRCA	TCGA	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1111
p.P991A	TCGA-DB-A64X	LGG	TCGA	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1667
p.P741S	TCGA-DQ-7596	HNSC	TCGA	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.0556
p.S955F	TCGA-EE-A2MR	SKCM	TCGA	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation altering degron motif	0.6871
p.P987H	TCGA-HJ-7597	STAD	TCGA	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.0556
p.E336V	TCGA-IN-AB1X	STAD	TCGA	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0833
p.T737I	TCGA-KQ-A41O	BLCA	TCGA	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.6111
p.T737I	SIDM00140	Melanoma	GDSC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.6111
p.T737I	ACH-000968	Skin Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.6111
p.T737I	COLO-792	skin	COSMIC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.6111
p.E314K	TCGA-PE-A5DD	BRCA	TCGA	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0833
p.E314K	DO219642	BRCA	ICGC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.0833
p.A723E	TCGA-QR-A7IP	PCPG	TCGA	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.2222
p.M725V	TCGA-YZ-A984	UVM	TCGA	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.2778
p.E322Q	DO2401	BRCA	ICGC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.3056
p.P728L	DO51734	COAD	ICGC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation altering degron motif	0.7582
p.P728L	DO42568	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation altering degron motif	0.7582
p.G959C	DO228986	LICA	ICGC	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation rewiring degron network	0.2778
p.S720P	DO50894	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.5833
p.S720P	SIDM01413	Oral Cavity Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.5833
p.S720P	ACH-000630	Head and Neck Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.5833
p.E998A	DO231824	LINC	ICGC	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation altering degron motif	0.7701
p.A721V	DO228322	MALY	ICGC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1667
p.S1565F	DO220857	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.25
p.S731G	DO229065	PRAD	ICGC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation altering degron motif	0.6993
p.S957L	DO229456	SKCA	ICGC	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation altering degron motif	0.7667
p.E321Q	DO38475	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2778
p.A330V	DO38404	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.T333A	DO47867	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.1667
p.S953Y	DO47849	STAD	ICGC	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation altering degron motif	0.712
p.T736A	DO43634	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.1944
p.R315W	DO41584	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation substituting flanking lysine	0.2222
p.E998D	DO41331	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation altering degron motif	0.6758
p.V1563L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1944
p.V1563L	ACH-000924	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1944
p.V1563L	NCI-H2172	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1944
p.P1578L	SIDM00625	Other Sarcomas	GDSC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1667
p.P1578L	SIDM01198	Burkitt's Lymphoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1667
p.P1578L	SIDM00472	Ovarian Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1568:1572	Mutation rewiring degron network	0.1667
p.T941I	SIDM01090	Colorectal Carcinoma	GDSC	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation rewiring degron network	0.0556
p.T941I	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation rewiring degron network	0.0556
p.T941I	SIDM01409	Bladder Carcinoma	GDSC	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation rewiring degron network	0.0556
p.T325I	SIDM00562	Breast Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7078
p.T325I	ACH-002163	Breast Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7078
p.T325I	MRK-nu-1	breast	COSMIC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation altering degron motif	0.7078
p.S739F	SIDM00562	Breast Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.5556
p.S739F	ACH-002163	Breast Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.5556
p.S739F	MRK-nu-1	breast	COSMIC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation blocking phosphorylation signal	0.5556
p.P991S	SIDM00327	Hodgkin's Lymphoma	GDSC	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1667
p.P991S	ACH-000754	Lymphoma	CCLE	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1667
p.P991S	L-428	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1667
p.L319V	SIDM01611	Endometrial Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2222
p.L319V	ACH-000996	Endometrial/Uterine Cancer	CCLE	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.2222
p.S730C	IST-SL2	lung	COSMIC	PVTSS	DEG_SPOP_SBC_1	727:731	Mutation altering degron motif	0.7541
p.L320F	COLO-679	skin	COSMIC	PKTTS	DEG_SPOP_SBC_1	323:327	Mutation rewiring degron network	0.25
p.K946N	NCI-H2227	lung	COSMIC	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation rewiring degron network	0.1944
p.A1000V	CW-2	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation altering degron motif	0.6936
p.C992R	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	997:1001	Mutation rewiring degron network	0.1944
p.F961L	BC-3	haematopoietic and lymphoid tissue	COSMIC	LQTPSLS	DEG_SCF_FBW7_1	951:957	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRDM2

UniProt ID: Q13029

Entrez ID: 7799

Protein name: PR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRDM2 in