DegronMD

Uniprot ID: Q13029

Source protein: PR domain zinc finger protein 2

Source gene: PRDM2

Class: DEG_SCF_FBW7_1

Location: 951:957

E3 ligase: FBXW7

DEGRON score: 0.9552

ASA_SCORE: 83.6

COIL: 0.9114

CONS_SCORE: 0.385

DSS_SCORE: 0.6378

HELIX: 0.0599

FCONS_SCORE: 0.9362

RIG_SCORE: 0.6343

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D943Y	TCGA-97-7554	LUAD	TCGA	LQTPSLS	DEG_SCF_FBW7_1	0.1111
p.D943Y	DO23592	LUAD	ICGC	LQTPSLS	DEG_SCF_FBW7_1	0.1111
p.S955F	TCGA-EE-A2MR	SKCM	TCGA	LQTPSLS	DEG_SCF_FBW7_1	0.6871
p.G959C	DO228986	LICA	ICGC	LQTPSLS	DEG_SCF_FBW7_1	0.2778
p.S957L	DO229456	SKCA	ICGC	LQTPSLS	DEG_SCF_FBW7_1	0.7667
p.S953Y	DO47849	STAD	ICGC	LQTPSLS	DEG_SCF_FBW7_1	0.712
p.T941I	SIDM01090	Colorectal Carcinoma	GDSC	LQTPSLS	DEG_SCF_FBW7_1	0.0556
p.T941I	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LQTPSLS	DEG_SCF_FBW7_1	0.0556
p.T941I	SIDM01409	Bladder Carcinoma	GDSC	LQTPSLS	DEG_SCF_FBW7_1	0.0556
p.K946N	NCI-H2227	lung	COSMIC	LQTPSLS	DEG_SCF_FBW7_1	0.1944
p.F961L	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	LQTPSLS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13029	PR domain zinc finger protein 2	DEG_SCF_FBW7_1	951:957	LQTPSLS	FBXW7	0.9552	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons