DegronMD - Q86UU1(PHLDB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S465F	TCGA-38-4631	LUAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.7982
p.S465F	DO24970	LUAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.7982
p.R466L	TCGA-55-8096	LUAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.8428
p.R466L	DO45343	LUAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.8428
p.S908L	TCGA-AA-A00N	COAD	TCGA	PKTTS	DEG_SPOP_SBC_1	904:908	Mutation altering degron motif	0.7667
p.S908L	DO9876	COAD	ICGC	PKTTS	DEG_SPOP_SBC_1	904:908	Mutation altering degron motif	0.7667
p.L416V	TCGA-AG-A01L	READ	TCGA	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation altering degron motif	0.5654
p.R901K	TCGA-B9-A44B	KIRP	TCGA	PKTTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.25
p.R901K	DO44496	KIRP	ICGC	PKTTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.25
p.R467Q	TCGA-BR-8680	STAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.6218
p.R467Q	DO47769	STAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.6218
p.Q297H	TCGA-D3-A2J6	SKCM	TCGA	ARSSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.1667
p.Q297H	DO37901	SKCM	ICGC	ARSSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.1667
p.R475Q	TCGA-D7-6526	STAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.2778
p.R475Q	DO222479	BTCA	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.2778
p.R475Q	DO38803	STAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.2778
p.R466Q	TCGA-DM-A28K	COAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.7329
p.R466Q	DO8167	COAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.7329
p.R427Q	TCGA-EY-A1GO	UCEC	TCGA	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1111
p.R427Q	DO41392	UCEC	ICGC	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1111
p.P286T	TCGA-HU-A4G8	STAD	TCGA	ARSSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.3056
p.P286T	DO47819	STAD	ICGC	ARSSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.3056
p.R427L	TCGA-KQ-A41N	BLCA	TCGA	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1111
p.R427L	DO223588	BLCA	ICGC	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1111
p.P480H	TCGA-VQ-A8P2	STAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1389
p.P480H	DO51761	STAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1389
p.K290N	DO651	BLCA	ICGC	ARSSS	DEG_SPOP_SBC_1	287:291	Mutation altering degron motif	0.6918
p.P480S	DO50331	ESAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation rewiring degron network	0.1389
p.R407C	DO228941	LICA	ICGC	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1111
p.G411V	DO229031	LICA	ICGC	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.2222
p.L406F	DO229038	LICA	ICGC	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.0833
p.G285C	DO229041	LICA	ICGC	ARSSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.2778
p.E912Q	DO50757	LICA	ICGC	PKTTS	DEG_SPOP_SBC_1	904:908	Mutation rewiring degron network	0.2222
p.P410L	DO220875	MELA	ICGC	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1944
p.P471L	DO222843	MELA	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	465:473	Mutation altering degron motif	0.6471
p.G411C	DO37966	SKCM	ICGC	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.2222
p.R288H	DO38404	STAD	ICGC	ARSSS	DEG_SPOP_SBC_1	287:291	Mutation altering degron motif	0.7133
p.P277S	DO41871	UCEC	ICGC	ARSSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.0556
p.S412N	SIDM00334	Endometrial Carcinoma	GDSC	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.25
p.S412N	ACH-000879	Endometrial/Uterine Cancer	CCLE	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.25
p.S412N	MFE-296	endometrium	COSMIC	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.25
p.Q297K	ACH-000972	Endometrial/Uterine Cancer	CCLE	ARSSS	DEG_SPOP_SBC_1	287:291	Mutation rewiring degron network	0.1667
p.P409A	ACH-002693	Sarcoma	CCLE	VLTTS	DEG_SPOP_SBC_1	415:419	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHLDB1

UniProt ID: Q86UU1

Entrez ID: 23187

Protein name: Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHLDB1 in