DegronMD

Uniprot ID: Q86UU1

Source protein: Pleckstrin homology-like domain family B member 1

Source gene: PHLDB1

Class: DEG_SPOP_SBC_1

Location: 415:419

E3 ligase: SPOP

DEGRON score: 0.9716

ASA_SCORE: 87.34

COIL: 0.8886

CONS_SCORE: 0.4381

DSS_SCORE: 0.713

HELIX: 0.0558

FCONS_SCORE: 1.0662

RIG_SCORE: 0.6764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L416V	TCGA-AG-A01L	READ	TCGA	VLTTS	DEG_SPOP_SBC_1	0.5654
p.R427Q	TCGA-EY-A1GO	UCEC	TCGA	VLTTS	DEG_SPOP_SBC_1	0.1111
p.R427Q	DO41392	UCEC	ICGC	VLTTS	DEG_SPOP_SBC_1	0.1111
p.R427L	TCGA-KQ-A41N	BLCA	TCGA	VLTTS	DEG_SPOP_SBC_1	0.1111
p.R427L	DO223588	BLCA	ICGC	VLTTS	DEG_SPOP_SBC_1	0.1111
p.R407C	DO228941	LICA	ICGC	VLTTS	DEG_SPOP_SBC_1	0.1111
p.G411V	DO229031	LICA	ICGC	VLTTS	DEG_SPOP_SBC_1	0.2222
p.L406F	DO229038	LICA	ICGC	VLTTS	DEG_SPOP_SBC_1	0.0833
p.P410L	DO220875	MELA	ICGC	VLTTS	DEG_SPOP_SBC_1	0.1944
p.G411C	DO37966	SKCM	ICGC	VLTTS	DEG_SPOP_SBC_1	0.2222
p.S412N	SIDM00334	Endometrial Carcinoma	GDSC	VLTTS	DEG_SPOP_SBC_1	0.25
p.S412N	ACH-000879	Endometrial/Uterine Cancer	CCLE	VLTTS	DEG_SPOP_SBC_1	0.25
p.S412N	MFE-296	endometrium	COSMIC	VLTTS	DEG_SPOP_SBC_1	0.25
p.P409A	ACH-002693	Sarcoma	CCLE	VLTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_SPOP_SBC_1	415:419	VLTTS	SPOP	0.9716	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons