DegronMD

Uniprot ID: Q86UU1

Source protein: Pleckstrin homology-like domain family B member 1

Source gene: PHLDB1

Class: DEG_APCC_DBOX_1

Location: 465:473

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7915

ASA_SCORE: 100.1333

COIL: 0.8874

CONS_SCORE: 0.3811

DSS_SCORE: 0.6996

HELIX: 0.0953

FCONS_SCORE: 0.7631

RIG_SCORE: 0.5997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S465F	TCGA-38-4631	LUAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	0.7982
p.S465F	DO24970	LUAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	0.7982
p.R466L	TCGA-55-8096	LUAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	0.8428
p.R466L	DO45343	LUAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	0.8428
p.R467Q	TCGA-BR-8680	STAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	0.6218
p.R467Q	DO47769	STAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	0.6218
p.R475Q	TCGA-D7-6526	STAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	0.2778
p.R475Q	DO222479	BTCA	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	0.2778
p.R475Q	DO38803	STAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	0.2778
p.R466Q	TCGA-DM-A28K	COAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	0.7329
p.R466Q	DO8167	COAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	0.7329
p.P480H	TCGA-VQ-A8P2	STAD	TCGA	SRRALSPLP	DEG_APCC_DBOX_1	0.1389
p.P480H	DO51761	STAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	0.1389
p.P480S	DO50331	ESAD	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	0.1389
p.P471L	DO222843	MELA	ICGC	SRRALSPLP	DEG_APCC_DBOX_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86UU1	Pleckstrin homology-like domain family B member 1	DEG_APCC_DBOX_1	465:473	SRRALSPLP	APC,CDC20,FZR1	0.7915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons