DegronMD - O75534(CSDE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R450I	TCGA-05-5423	LUAD	TCGA	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation substituting flanking lysine	0.3056
p.R450I	TCGA-AA-A010	COAD	TCGA	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation substituting flanking lysine	0.3056
p.R450I	SIDM00118	Colorectal Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation substituting flanking lysine	0.3056
p.R450I	HCC2998	large intestine	COSMIC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation substituting flanking lysine	0.3056
p.P443S	TCGA-EE-A20C	SKCM	TCGA	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.6752
p.G448R	DO233715	GACA	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation substituting flanking lysine	0.3611
p.D431G	DO12520	GBM	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation blocking phosphorylation signal	0.5
p.T452N	DO14478	HNSC	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation blocking ubiquitination signal	0.5833
p.I454M	DO26870	LUSC	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.0833
p.G434W	DO27652	LUSC	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation blocking ubiquitination signal	0.5833
p.N455S	DO222670	MELA	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.0556
p.N455S	DO38057	SKCM	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.0556
p.T446M	DO47827	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.R442H	DO47757	STAD	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.8244
p.T438A	DO223286	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.25
p.H436N	DO43971	UCEC	ICGC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1944
p.I433M	SIDM00544	Neuroblastoma	GDSC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.I433M	SIDM00315	Glioblastoma	GDSC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.I433M	SIDM00358	Gastric Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.I433M	SIDM00554	Ovarian Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.I433M	SIDM00166	Other Solid Cancers	GDSC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.I433M	YKG-1	central nervous system	COSMIC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.I433M	RERF-GC-1B	stomach	COSMIC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.I433M	KURAMOCHI	ovary	COSMIC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.I433M	GOTO	autonomic ganglia	COSMIC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.R450K	SIDM00534	Colorectal Carcinoma	GDSC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation substituting flanking lysine	0.3056
p.R450K	HT-115	large intestine	COSMIC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation substituting flanking lysine	0.3056
p.P446A	CGTH-W-1	thyroid	COSMIC	PKTTS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056

Kaplan plot for CSDE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSDE1

UniProt ID: O75534

Entrez ID: 7812

Protein name: Cold shock domain-containing protein E1 (N-ras upstream gene protein) (Protein UNR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSDE1 in