DegronMD

Uniprot ID: Q8N131

Source protein: Porimin

Source gene: TMEM123

Class: DEG_SCF_FBW7_1

Location: 112:119

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 107.725

COIL: 0.9468

CONS_SCORE: 0.5181

DSS_SCORE: 0.5701

HELIX: 0.0153

FCONS_SCORE: 1.3888

RIG_SCORE: 0.7032

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q127E	TCGA-49-4486	LUAD	TCGA	LKSTPKTT	DEG_SCF_FBW7_1	0.1111
p.Q127E	TCGA-DK-A3WW	BLCA	TCGA	LKSTPKTT	DEG_SCF_FBW7_1	0.1111
p.P116S	TCGA-AX-A1CE	UCEC	TCGA	LKSTPKTT	DEG_SCF_FBW7_1	0.6752
p.S126F	TCGA-BB-8601	HNSC	TCGA	LKSTPKTT	DEG_SCF_FBW7_1	0.1389
p.D114Y	DO43154	UCEC	ICGC	LKSTPKTT	DEG_SCF_FBW7_1	0.7325
p.A118V	DO41199	UCEC	ICGC	LKSTPKTT	DEG_SCF_FBW7_1	0.6936
p.M107V	SIDM00901	Endometrial Carcinoma	GDSC	LKSTPKTT	DEG_SCF_FBW7_1	0.1944
p.M107V	ACH-000940	Endometrial/Uterine Cancer	CCLE	LKSTPKTT	DEG_SCF_FBW7_1	0.1944
p.M107V	AN3-CA	endometrium	COSMIC	LKSTPKTT	DEG_SCF_FBW7_1	0.1944
p.V116I	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LKSTPKTT	DEG_SCF_FBW7_1	0.7076
p.R105G	NCI-H596	lung	COSMIC	LKSTPKTT	DEG_SCF_FBW7_1	0.1389
p.G107D	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LKSTPKTT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N131	Porimin	DEG_SCF_FBW7_1	112:119	LKSTPKTT	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons