DegronMD

Uniprot ID: Q5HYW2

Source protein: NHS-like protein 2

Source gene: NHSL2

Class: DEG_SPOP_SBC_1

Location: 774:778

E3 ligase: SPOP

DEGRON score: 0.9452

ASA_SCORE: 84.38

COIL: 0.9594

CONS_SCORE: 0

DSS_SCORE: 0.4077

HELIX: 0.015

FCONS_SCORE: 0

RIG_SCORE: 0.6988

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P779S	TCGA-33-4583	LUSC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.3056
p.P774S	TCGA-AP-A051	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.6752
p.R768Q	TCGA-AP-A0LM	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1667
p.R768Q	DO43306	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1667
p.G785V	TCGA-BH-A18G	BRCA	TCGA	PLTSS	DEG_SPOP_SBC_1	0.1389
p.F764C	TCGA-BS-A0UF	UCEC	TCGA	PLTSS	DEG_SPOP_SBC_1	0.0556
p.F764C	TCGA-CA-6717	COAD	TCGA	PLTSS	DEG_SPOP_SBC_1	0.0556
p.F764C	DO8264	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0556
p.F764C	DO41488	UCEC	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0556
p.S770L	TCGA-D3-A5GO	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	0.2222
p.D782N	TCGA-EE-A29L	SKCM	TCGA	PLTSS	DEG_SPOP_SBC_1	0.2222
p.D782N	DO222599	MELA	ICGC	PLTSS	DEG_SPOP_SBC_1	0.2222
p.D782N	DO37835	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.2222
p.V773I	DO7776	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	0.3056
p.T785I	DO7843	COAD	ICGC	PLTSS	DEG_SPOP_SBC_1	0.1389
p.V779L	DO26052	LUAD	ICGC	PLTSS	DEG_SPOP_SBC_1	0.3056
p.P787H	DO47442	SKCM	ICGC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.P765S	SIDM00392	Melanoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.P765S	SK-MEL-30	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.0833
p.K766E	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLTSS	DEG_SPOP_SBC_1	0.2222
p.K766E	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.2222
p.P788T	NCI-H650	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.0556
p.V779G	TGBC1TKB	biliary_tract	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.3056
p.L777M	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.711
p.G774C	NCI-H2347	lung	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.76
p.G774S	WM-115	skin	COSMIC	PLTSS	DEG_SPOP_SBC_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43586	Proline-serine-threonine phosphatase-interacting protein 1	DEG_SPOP_SBC_1	294:298	PLTSS	SPOP	0.9863	More...
O60284	Suppression of tumorigenicity 18 protein	DEG_SPOP_SBC_1	629:633	PLTSS	SPOP	0.9793	More...
O75563	Src kinase-associated phosphoprotein 2	DEG_SPOP_SBC_1	249:253	PLTSS	SPOP	0.9972	More...
O95486	Protein transport protein Sec24A	DEG_SPOP_SBC_1	226:230	PLTSS	SPOP	0.9934	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	1024:1028	PLTSS	SPOP	0.8767	More...
P49736	DNA replication licensing factor MCM2	DEG_SPOP_SBC_1	23:27	PLTSS	SPOP	0.9038	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1038:1042	PLTSS	SPOP	0.6344	More...
Q15475	Homeobox protein SIX1	DEG_SPOP_SBC_1	274:278	PLTSS	SPOP	0.5507	More...
Q15691	Microtubule-associated protein RP/EB family member 1	DEG_SPOP_SBC_1	152:156	PLTSS	SPOP	0.9872	More...
Q17RY0	Cytoplasmic polyadenylation element-binding protein 4	DEG_SPOP_SBC_1	157:161	PLTSS	SPOP	0.9878	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	774:778	PLTSS	SPOP	0.9452	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	355:359	PLTSS	SPOP	0.9297	More...
Q6ZRS2	Helicase SRCAP	DEG_SPOP_SBC_1	254:258	PLTSS	SPOP	0.949	More...
Q7Z434	Mitochondrial antiviral-signaling protein	DEG_SPOP_SBC_1	189:193	PLTSS	SPOP	0.9989	More...
Q8NEP3	Dynein axonemal assembly factor 1	DEG_SPOP_SBC_1	671:675	PLTSS	SPOP	0.9436	More...
Q8WXI2	Connector enhancer of kinase suppressor of ras 2	DEG_SPOP_SBC_1	775:779	PLTSS	SPOP	0.8711	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	1750:1754	PLTSS	SPOP	0.9632	More...
Q96RU2	Ubiquitin carboxyl-terminal hydrolase 28	DEG_SPOP_SBC_1	514:518	PLTSS	SPOP	0.9579	More...
Q96RW7	Hemicentin-1	DEG_SPOP_SBC_1	2817:2821	PLTSS	SPOP	0.5877	More...
Q99633	Pre-mRNA-splicing factor 18	DEG_SPOP_SBC_1	58:62	PLTSS	SPOP	0.9188	More...
Q9BZE9	Tether containing UBX domain for GLUT4	DEG_SPOP_SBC_1	261:265	PLTSS	SPOP	0.9718	More...
Q9C0B0	RING finger protein unkempt homolog	DEG_SPOP_SBC_1	468:472	PLTSS	SPOP	0.7927	More...
Q9NPI1	Bromodomain-containing protein 7	DEG_SPOP_SBC_1	120:124	PLTSS	SPOP	0.9763	More...
Q9UDV6	Zinc finger protein 212	DEG_SPOP_SBC_1	17:21	PLTSS	SPOP	0.99	More...
Q9UHK0	Nuclear fragile X mental retardation-interacting protein 1	DEG_SPOP_SBC_1	49:53	PLTSS	SPOP	0.9611	More...
Q6ZMY3	SPOC domain-containing protein 1	DEG_SPOP_SBC_1	193:197	PLTSS	SPOP	0.8764	More...
Q8IWR0	Zinc finger CCCH domain-containing protein 7A	DEG_SPOP_SBC_1	347:351	PLTSS	SPOP	0.9188	More...
O94880	PHD finger protein 14	DEG_SPOP_SBC_1	568:572	PLTSS	SPOP	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLTSS

Degron related mutations and impact score

Drug responses associated with NHSL2 mutations

All proteins holding degron of PLTSS